Characterization of the Cardiac Reinnervation of Patients With Transposition of the Great Arteries Long After Repair With the Arterial Switch Operation. Correlation With Electrocardiographic and Exercise Test Parameters

Related Clinical Trial
Clinical Impact of Rapid Prototyping 3D Models for Surgical Management A Retrospective Comparison of the Efficacy and Safety of Celsior® in Pediatric Cardiac Surgery for Transposition of the Great Vessels Comprehensive Long-term Follow up of Adults With Arterial Switch Operation Erythropoetin Neuroprotection for Neonatal Cardiac Surgery Initiation of Resuscitation While Attached to the Cord With Congenital Heart Disease Canadian Adult Congenital Heart Disease Intervention Registry Physical Training in Transposition of the Great Arteries Eplerenone in Systemic Right Ventricle N-Acetylcysteine in Neonatal Congenital Heart Surgery (INACT Study) Genetic Determinants of Congenital Heart Disease Outcomes Myocardial Contrast Echocardiography in Congenital Heart Disease Sudden Cardiac Death in Systemic Right Ventricle Haemodynamics and Function of the Atria in Congenital Heart Disease by Cardiovascular Magnetic Resonance The Boston Circulatory Arrest Study: Antecedents and Correlates of Well-Being in Adults With Congenital Heart Disease Comparison of Hematocrit Levels in Infant Heart Surgery Late Function After Surgery for Transposition of the Great Arteries Acute Maternal Hyperoxygenation for Fetal Transposition of the Great Arteries (TGA) MRI Study After Arterial Switch Operation in Patients With Transposition of the Great Arteries Fibrosis, Valvular and Ventricular Function in Patients With TGA Characterization of the Cardiac Reinnervation of Patients With Transposition of the Great Arteries Long After Repair With the Arterial Switch Operation. Correlation With Electrocardiographic and Exercise Test Parameters Cardiovascular MRI and Cardiopulmonary Exercise Capacity After Neonatal ASO) in Young Adults Nitric Oxide During Bypass for Arterial Switch Operation

Brief Title

Characterization of the Cardiac Reinnervation of Patients With Transposition of the Great Arteries Long After Repair With the Arterial Switch Operation. Correlation With Electrocardiographic and Exercise Test Parameters

Official Title

Characterization of the Cardiac Reinnervation of Patients With Transposition of the Great Arteries Long After Repair With the Arterial Switch Operation. Correlation With Electrocardiographic and Exercise Test Parameters

Brief Summary

      Cardiac denervation is inherent to the arterial switch (ASO) technique for the repair of
      transposition of the great arteries (TGA) and the long term reinnervation process has not
      been studied. We sought to describe the reinnervation status of adult patients long after the
      ASO, to identify areas of myocardial perfusion/innervation mismatch and to assess the
      relation of innervation status and exercise capacity.
    

Detailed Description

      Cardiac denervation is inherent to the arterial switch (ASO) technique for the repair of
      transposition of the great arteries (TGA) and the long term reinnervation process has not
      been studied. We sought to describe the reinnervation status of adult patients long after the
      ASO, to identify areas of myocardial perfusion/innervation mismatch and to assess the
      relation of innervation status and exercise capacity.
    


Study Type

Observational


Primary Outcome

Myocardial innervation pattern on 123I-mlBG SPECT.

Secondary Outcome

 Myocardial perfusion defects on cardiac nuclear imaging.

Condition

Congenital Heart Disease

Intervention

Non intervention

Study Arms / Comparison Groups

 Patients
Description:  patients with transposition of the great arteries long after repair with the arterial switch operation

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Other

Estimated Enrollment

60

Start Date

April 19, 2018

Completion Date

September 1, 2019

Primary Completion Date

March 1, 2019

Eligibility Criteria

        Inclusion Criteria:

          -  Patients with transposition of the great arteries repaired with the arterial switch.

          -  Patients aged of more than 18 years-old.

        Exclusion Criteria:

          -  Pregnancy or breast-feeding.

          -  Denial of informed consent.
      

Gender

All

Ages

18 Years - N/A

Accepts Healthy Volunteers

No

Contacts

Laura Dos Subirà, PhD MD, 932746170, [email protected]

Location Countries

Spain

Location Countries

Spain

Administrative Informations


NCT ID

NCT03469843

Organization ID

PR(AMI)126/2015


Responsible Party

Sponsor

Study Sponsor

Hospital Universitari Vall d'Hebron Research Institute


Study Sponsor

Laura Dos Subirà, PhD MD, Principal Investigator, Hospital Universitari Vall d'hebron Barcelona, Spain


Verification Date

March 2018