Haemodynamics and Function of the Atria in Congenital Heart Disease by Cardiovascular Magnetic Resonance

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Brief Title

Haemodynamics and Function of the Atria in Congenital Heart Disease by Cardiovascular Magnetic Resonance

Official Title

Haemodynamics and Function of the Atria in Patients With Congenital Heart Defects - Pilot Study by Cardiovascular Magnetic Resonance

Brief Summary

      The purpose of this study is to determine whether patients with repaired congenital heart
      disease show differences in size or function of their heart atria compared to normal controls
      and depending on the nature of their heart disease.
    

Detailed Description

      Atrial function is important for good ventricular filling and function. In patients with
      impaired cardiac function, atrial contraction is even more important. So far, the size and
      function of the atria have been assessed two-dimensionally by angiography and by
      echocardiography. However, these do not allow exact characterization of the volumetric
      changes of the atria during the cardiac cycle. Recently, cardiac magnetic resonance (CMR) has
      been used to assess size and function of the left atrium in adults. Little data are available
      about function and volume of the atria in children and the role of the atria in congenital
      heart disease (CHD).

      The study will recruit patients with CHD (n=40) and normal controls (n=10). The patient group
      will be composed by patients suffering from the following conditions: coarctation of the
      aorta (n=10), tetralogy of Fallot (n=10), transposition of the great arteries after atrial
      switch (Senning procedure) (n=10), transposition of the great arteries after arterial switch
      operation (n=10).

      The study consists of measurements of sizes and function of the right and the left atrium,
      respectively, by examining three-dimensional volume changes across the heart cycle, and of
      phase contrast measurements of blood flow across the valves of the heart.
    


Study Type

Observational


Primary Outcome

Right and left atrial volume

Secondary Outcome

 Blood flow across the atrio-ventricular valves

Condition

Coarctation of the Aorta


Study Arms / Comparison Groups

 Aortic coarctation
Description:  Patients after repair of coarctation of the aorta

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information



Estimated Enrollment

50

Start Date

October 2009

Completion Date

December 2020

Primary Completion Date

November 2020

Eligibility Criteria

        Inclusion Criteria:

          -  Ability to perform repetitive breath holds of 10-15 seconds each

          -  Written informed consent of the patients or their legal guardians

        Exclusion Criteria:

          -  Patients requiring general anaesthesia

          -  Residual cardiac findings which might potentially influence the size and function of
             the atria
      

Gender

All

Ages

8 Years - N/A

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Contacts

Emanuela R Valsangiacomo Buechel, Prof., , 

Location Countries

Switzerland

Location Countries

Switzerland

Administrative Informations


NCT ID

NCT02161471

Organization ID

Atrial function in CHD by CMR


Responsible Party

Sponsor

Study Sponsor

University Children's Hospital, Zurich


Study Sponsor

Emanuela R Valsangiacomo Buechel, Prof., Principal Investigator, University Children's Hospital Zürich, Switzerland


Verification Date

July 2019