Imaging Study of Neurovascular Coupling in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL)

Brief Title

Imaging Study of Neurovascular Coupling in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL)

Official Title

Etude Comparative en Imagerie Par résonnance magnétique et Par Enregistrement électroencéphalographique du Couplage Neurovasculaire Dans l'Angiopathie Cadasil

Brief Summary

      The aim of this study is to investigate using fMRI methods, EEG and dedicated mathematical
      models, the potential alterations of neurovascular coupling in CADASIL.
    

Detailed Description

      Comparison study of parameters derived from mathematical models of neurovascular coupling and
      obtained using fMRI (Bold signal, ASL and EEG).
    


Study Type

Observational


Primary Outcome

model-derived parameters of neurovascular coupling


Condition

CADASIL



Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information



Estimated Enrollment

60

Start Date

January 2015

Completion Date

January 2018

Primary Completion Date

January 2018

Eligibility Criteria

        Inclusion Criteria:

          -  CADASIL group: typical NOTCH3 mutation, age less than 60 years, rankin score at 0-1,
             active social insurance

        Exclusion Criteria:

          -  MRI contra-indications and use of any treatment known to interfere with neurovascular
             coupling, pregnancy, lack of informed consent
      

Gender

All

Ages

18 Years - 60 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Contacts

Hugues Chabriat, MD PhD, , 

Location Countries

France

Location Countries

France

Administrative Informations


NCT ID

NCT02071784

Organization ID

C13-62

Secondary IDs

2014-A00200-47

Responsible Party

Sponsor

Study Sponsor

Institut National de la Santé Et de la Recherche Médicale, France


Study Sponsor

Hugues Chabriat, MD PhD, Principal Investigator, INSERM and APHP


Verification Date

February 2016