CADASIL Registry Study

Brief Title

CADASIL Registry Study

Official Title

Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Registry Study

Brief Summary

      The aim of this study is to determine the clinical spectrum and natural progression of
      Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
      (CADASIL) and related disorders in a prospective multicenter study, to assess the clinical,
      genetic and epigenetic features of patients with CADASIL , to optimize clinical management.
    



Study Type

Observational


Primary Outcome

Overall outcomes in CADASIL patients

Secondary Outcome

 The correlation of genotype and phenotype

Condition

Cadasil


Study Arms / Comparison Groups

 CADASIL patients
Description:  

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information



Estimated Enrollment

1000

Start Date

March 9, 2020

Completion Date

March 9, 2049

Primary Completion Date

March 9, 2039

Eligibility Criteria

        Inclusion Criteria:

          1. Sign informed consent.

          2. Age>18

          3. Clinical diagnosis of patients with CADASIL,and confirmed by genetic test or skin
             biopsy

          4. Asymptomatic NOTCH3 mutation carriers

          5. Relatives of CADASIL patients or carriers

          6. Unrelated healthy controls

        Exclusion Criteria:

          1. Unable to cooperate with inspectors

          2. Serious systemic illness, such as heart, liver, kidney disease or major mental illness

          3. Contraindications for imaging examination
      

Gender

All

Ages

18 Years - 85 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Contacts

, 13615039153, [email protected]

Location Countries

China

Location Countries

China

Administrative Informations


NCT ID

NCT04310098

Organization ID

MRCTA,ECFAH of FMU [2019]244-1


Responsible Party

Sponsor-Investigator

Study Sponsor

Bin Cai


Study Sponsor

, , 


Verification Date

March 2020