Brief Title
CADASIL Registry Study
Official Title
Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Registry Study
Brief Summary
The aim of this study is to determine the clinical spectrum and natural progression of
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
(CADASIL) and related disorders in a prospective multicenter study, to assess the clinical,
genetic and epigenetic features of patients with CADASIL , to optimize clinical management.
Study Type
Observational
Primary Outcome
Overall outcomes in CADASIL patients
Secondary Outcome
The correlation of genotype and phenotype
Condition
Cadasil
Study Arms / Comparison Groups
CADASIL patients
Description:
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Estimated Enrollment
1000
Start Date
March 9, 2020
Completion Date
March 9, 2049
Primary Completion Date
March 9, 2039
Eligibility Criteria
Inclusion Criteria:
1. Sign informed consent.
2. Age>18
3. Clinical diagnosis of patients with CADASIL,and confirmed by genetic test or skin
biopsy
4. Asymptomatic NOTCH3 mutation carriers
5. Relatives of CADASIL patients or carriers
6. Unrelated healthy controls
Exclusion Criteria:
1. Unable to cooperate with inspectors
2. Serious systemic illness, such as heart, liver, kidney disease or major mental illness
3. Contraindications for imaging examination
Gender
All
Ages
18 Years - 85 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Contacts
, 13615039153, [email protected]
Location Countries
China
Location Countries
China
Administrative Informations
NCT ID
NCT04310098
Organization ID
MRCTA,ECFAH of FMU [2019]244-1
Responsible Party
Sponsor-Investigator
Study Sponsor
Bin Cai
Study Sponsor
, ,
Verification Date
March 2020