Treatments

The following database contains products that have been granted orphan status, or have been market approval in the EU or the USA.

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Country Product Indication Sponsor Date
Clonazepam Hyperekplexia (startle disease) Hoffmann-La Roche, Inc.;340 Kingsland Street;Nutley, New Jersey, 07110 August 4, 1994
Busulfan As preparative therapy in the treatment of malignancies with bone marrow transplantation Otsuka Pharmaceutical Company;Tokyo; July 28, 1994
Gammalinolenic acid Juvenile rheumatoid arthritis Zurier, Robert B. M.D.;University of Massachusetts Medical Center, 55 Lake Avenue;Worcester, Massachusetts, 01655 July 27, 1994
Dehydroepiandrosterone Systemic lupus erythematosus (SLE) and the reduction in the use of steroids in steroid-dependent SLE patients GlaxoSmithKline;P. O. Box 13398, Five Moore Drive;Research Triangle Park, North Carolina, 27709 July 13, 1994
Autolymphocyte therapy Renal cancer Cytogen Corporation;600 College Road East, CN 5308;Princeton, New Jersey, 08540 July 12, 1994
Liposome encapsulated recombinant interleukin-2 Cancers of the kidney and renal pelvis Oncothyreon Canada, Inc.;2011 - 94th Street NW, Canada T6N 1H1; June 20, 1994
Buprenorphine hydrochloride Opiate addiction in opiate users Indivior, Inc.;10710 Midlothian Turnpike, Suite 430;Richmond, Virginia, 23235 June 15, 1994
L-2-oxothiazolidine-4-carboxylic acid Adult respiratory distress syndrome Transcend Therapeutics, Inc.;640 Memorial Drive, 3rd Floor West;Cambridge, Massachusetts, 02139 June 14, 1994
Arginine butyrate Sickle cell anemia Vertex Pharmaceuticals Inc.;130 Waverly Street;Cambridge, Massachusetts, 02139 May 25, 1994
Isobutyramide Sickle cell anemia Alpha Therapeutic Corporation;5555 Valley Boulevard;Los Angeles, California, 90032 May 25, 1994
Ganaxolone West syndrome Marinus Pharmaceuticals, Inc.;21 Business Park Drive;Branford, Connecticut, 06405 May 25, 1994
Valrubicin Carcinoma in situ of the urinary bladder Anthra Pharmaceuticals, Inc.;103 Carnegie Center, Suite 102;Princeton, New Jersey, 08540 May 23, 1994
Tositumomab and iodine I 131 tositumomab Non-Hodgkin's B-cell lymphoma GlaxoSmithKline LLC;Corporation Service Company, 2711 Centerville Road, Suite 400;Wilmington, Delaware, 19808 May 16, 1994
L-cysteine For the prevention and lessening of photosensitivity in erythropoietic protoporphyria Brigham and Women's Hospital;Channing Laboratory, 181 Longwood Ave.;Boston, Massachusetts, 02115 May 16, 1994
Treosulfan Ovarian cancer Medac GmbH;Fehlandtstrasse 3, D-20354 Hamburg; May 16, 1994
Betaine Homocystinuria Orphan Europe SARL;70 Avenue du G�n�ral de Gaulle;Puteaux May 16, 1994
Methoxsalen For the prevention of acute rejection of cardiac allografts Therakos, Inc.;10 North High Street, Suite 300;West Chester, Pennsylvania, 19380 May 12, 1994
8-methoxsalen For the prevention of acute rejection of cardiac allografts Therakos, Inc.;Oaklands Corporate Center, 437 Creamery Way;Exton, PA, 19341 May 12, 1994
Busulfan For use as preparative therapy for malignancies treated with bone marrow transplantation Sparta Pharmaceuticals, Inc.;111 Rock Road;Horsham, Pennsylvania, 19044 April 21, 1994
Cladribine The chronic progressive form of multiple sclerosis Johnson & Johnson Pharmaceutical R & D, LLC;920 Route 202, PO Box 300;Raritan, New Jersey, 08869 April 19, 1994
Mitoguazone Diffuse non-Hodgkin's lymphoma, including AIDS-related diffuse non-Hodgkin's lymphoma ILEX Oncology, Inc.;4545 Horizon Hill Blvd.;San Antonio, Texas, 78229 March 18, 1994
Oxandrolone Moderate/severe acute alcoholic hepatitis in the presence of moderate protein calorie malnutrition Bio-Technology General Corp.;70 Wood Avenue South;Iselin, New Jersey, 08830 March 18, 1994
Amiodarone HCl For the acute treatment and prophylaxis of life-threatening ventricular tachycardia or ventricular fibrillation Wyeth-Ayerst Laboratories;P.O. Box 8299;Philadelphia, Pennsylvania, 19101 March 16, 1994
Immunotherapeutic vaccine consisting of (PAM)2-Lys-Ser-Ser-Gln-Tyr-Ile-Lys-Ala-Asn-Ser-Lys-Phe-Ile-Gly-Ile-Thr-Glu-Ala-Ala-Ala-Phe-Leu-Pro-Ser-Asp-Phe-Phe-Pro-Ser-Val Chronic active hepatitis B infection in HLA-A2 positive patients Cytel Corporation;3525 John Hopkins Court;San Diego, California, 92121 March 16, 1994
Sulfadiazine For use in combination with pyrimethamine for the treatment of Toxoplasma gondii encephalitis in patients with and without AIDS Eon Labs Manufacturing, Inc.;227-15 North Conduit Avenue;Laurelton, New York, 11413 March 14, 1994