Treatments

The following database contains products that have been granted orphan status, or have been market approval in the EU or the USA.

You can filter the content by clicking on the titles: Product, Indication, Sponsor and Date. Clicking once, will filter the column alphabetically from A – Z and a second click on the same title will filter from Z – A.

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Country Product Indication Sponsor Date
Bovine immunoglobulin concentrate, Cryptosporidium parvum Cryptosporidiosis GalaGen, Inc.;4001 Lexington Avenue North;Arden Hills, Minnesota, 55126 March 1, 1994
Heme arginate Myelodysplastic syndromes Orphan Europe;Immeuble Le Wilson, 70 avenue du General de Gaulle,;92800 Puteaux March 1, 1994
Reduced L-glutathione AIDS-associated cachexia Telluride Pharmaceutical Corporation;146 Flanders Drive;Hillsborough, New Jersey, 08876 February 14, 1994
Exisulind For the suppression and control of colonic adenomatous polyps in the inherited disease adenomatous polyposis coli OSI Pharmaceuticals, Inc.;41 Pinelawn Road;Melville, New York, 11747 February 14, 1994
Choline chloride Choline deficiency, specifically the choline deficiency, hepatic steatosis, and cholestasis, associated with long-term parenteral nutrition Alan L. Buchman, MD, MSPH;959 Oak Drive;Glencoe, Illinois, 60022 February 10, 1994
Tizanidine HCl Spasticity associated with multiple sclerosis and spinal cord injury Athena Neurosciences, Inc.;800 Gateway Boulevard;South San Francisco, California, 94080 January 31, 1994
Ammonium tetrathiomolybdate Wilson disease Pipex Pharmaceuticals, Inc.;3930 Varsity Drive;Ann Arbor, Michigan, 48108 January 31, 1994
Antivenin, crotalidae polyvalent immune Fab (ovine) Envenomations inflicted by North American crotalid snakes Protherics, Inc.;1207 17th Ave. S., Suite 103;Nashville, Tennessee, 37212 January 12, 1994
Recombinant human gelsolin The respiratory symptoms of cystic fibrosis BioAegis Therapeutics, Inc.;6 East Cove Lane;Morristown, New Jersey, 07960 January 12, 1994
Neutrophil-endothelial interaction inhibitor Post-ischemic pulmonary reperfusion edema following surgical treatment for chronic thromboembolic pulmonary hypertension Cytel Corporation;3525 John Hopkins Court;San Diego, California, 92121 December 22, 1993
Beractant Persistent pulmonary hypertension of the newborn Ross Laboratories;625 Cleveland Avenue;Columbus, Ohio, 43215 December 20, 1993
5a8, monoclonal antibody to CD4 For use in post-exposure prophylaxis for occupational exposure to human immunodeficiency virus Biogen, Inc.;14 Cambridge Center;Cambridge, Massachusetts, 02142 December 20, 1993
Hemin and zinc mesoporphyrin Acute porphyric syndromes Bonkovsky, Herbert L. M.D.;University Of Massachusetts Medical Center, 55 Lake Avenue North;Worcester, Massachusetts, 01655 December 20, 1993
Epoetin alfa Myelodysplastic syndrome Johnson & Johnson Pharmaceutical Research & Dev.,;920 U.S. Highway, Route 202, P.O. Box 300;Raritan, New Jersey, 08869 December 20, 1993
Sacrosidase Congenital Sucrase-Isomaltase Deficiency QOL Medical, LLC;4445 North Highway, A1A, 241;Vero Beach, Florida, 32963 December 10, 1993
Poly I: poly C12U Chronic fatigue syndrome Hemispherx Biopharma, Inc.;One Penn Center, 1617 JFK Boulevard;Philadelphia, PA, 19103 December 9, 1993
Poly I: poly C12U Metastatic Melanoma Hemispherx Biopharma, Inc.;One Penn Center, 1617 JFK Boulevard;Philadelphia, Pennsylvania, 19103 December 9, 1993
Poly I: poly C12U Chronic fatigue syndrome Hemispherx Biopharma, Inc.;One Penn Center, 1617 JFK Boulevard;Philadelphia, Pennsylvania, 19103 December 9, 1993
Levocarnitine Pediatric cardiomyopathy Leadiant Biosciences, Inc.;9841 Washingtonian Blvd, Suite 500;Gaithersburg, Maryland, 20878 November 22, 1993
Immune globulin intravenous (human) Patients with acute myocarditis Immuno Clinical Research Corp.;750 Lexington Avenue;New York, New York, 10022 November 22, 1993
Benzoate/phenylacetate Acute hyperammonemia and associated encephalopathy in patients with deficiencies in enzymes of the urea cycle Medicis Pharmaceutical Corp.;8125 N. Hayden Road;Scottsdale, Arizona, 85258 November 22, 1993
Aprotinin For prophylactic use to reduce perioperative blood loss and the homologous blood transfusion requirement in patients undergoing cardiopulmonary bypass surgery in the course of repeat coronary artery bypass graft surgery, and in selected cases of primary coronary artery bypass graft surgery where the risk of bleeding is especially high (impaired hemostasis) or where transfusion is unavailable or unacceptable Bayer Corporation;Pharmaceutical Division, 400 Morgan Lane;West Haven, Connecticut, 06516 November 17, 1993
Aminosidine Mycobacterium avium complex Kanyok, Thomas P. Pharm.D.;University Of Illinois At Chicago College of Pharm, 833 South Wood Street (m/c886) Rm. 176;Chicago, Illinois, 60612 November 15, 1993
Melatonin Circadian rhythm sleep disorders in blind people with no light perception Sack, Robert, M.D.;Oregon Health Sciences University, 3181 S.W. Sam Jackson Park Road;Portland, Oregon, 97201 November 15, 1993
Recombinant retroviral vector – glucocerebrosidase For use as enzyme replacement therapy for patients with types I, II, or III Gaucher disease Genetic Therapy, Inc.;938 Clopper Road;Gaithersburg, Maryland, 20878 November 15, 1993