Treatments

The following database contains products that have been granted orphan status, or have been market approval in the EU or the USA.

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Country Product Indication Sponsor Date
Autologous or allogeneic limbal epithelial stem cells expanded ex vivo on human amniotic membrane Ocular surface diseases that are characterized by total limbal stem cell deficiency TissueTech, Inc.;7000 SW 97th Avenue;Miami, Florida, 33173 July 14, 2005
Recombinant human lysosomal acid lipase or cholesteryl ester hydrolase Cholesteryl Ester Storage Disease Lysosomal Acid Lipase, LLC;Subsidiary of Kentucky BioProcessing, LLC, 3700 Airpark Drive;Owensboro, Kentucky, 42301 July 14, 2005
Alfentanil Management of postherpetic neuralgia Cinergen, LLC;146 Medinah Drive;Blue Bell, Pennsylvania, 19422 July 8, 2005
SDF-1 (108) Lysine Dlmer Pediatric osteosarcoma Chemokine Therapeutics Corporation;190 Agronomy Road (UBC), Suite 405;Vancouver, BC V6T 1Z3 July 7, 2005
Contulakin-G Intrathecal treatment of neuropathic pain associated with spinal cord injury Cognetix, Inc.;421 Wakara Way;Salt Lake City, Utah, 84108 July 7, 2005
Valproic acid, sodium Familial adenomatous polyposis Topotarget A/S;Fruebjergvej 3, DK-2100;Copenhagen June 24, 2005
Recombinant truncated SPINT2 protease inhibitor Cystic fibrosis Aerovance, Inc.;2929 Seventh Street;Berkeley, California, 94710 June 24, 2005
Liposomal annamycin Acute lymphoblastic leukemia Callisto Pharmaceuticals, Inc.;420 Lexington Avenue;New York, New York, 10170 June 17, 2005
Liposomal annamycin Acute myeloid leukemia Callisto Pharmaceuticals, Inc.;420 Lexington Avenue;New York, New York, 10170 June 17, 2005
Adenoviral vector expressing Herpes simplex virus thymidine kinase gene Malignant brain tumors Advantagene, Inc.;160 Paulson Road;Waban, Massachusetts, 02468 June 17, 2005
Clotrimazole Topical treatment of children and adults with pouchitis AesRx, LLC;275 Grove Street, Suite 2-400;Newton, Massachusetts, 02466 June 14, 2005
Geneticin Amoebiasis ProcesScience, Inc (PSI);117 Woodberry Lane;Fayetteville, New York, 13066 June 6, 2005
Polyethylene glycol-modified uricase Hyperuricemia in patients with gout refractory to conventional therapy or in whom conventional therapy is contraindicated EnzymeRx, LLC;17 Arcadian Avenue, Suite 104;Paramus, New Jersey, 07652 June 6, 2005
Tacrolimus Prophylaxis of organ rejection in patients receiving heart transplants Astellas Pharma US, Inc.;Three Parkway North;Deerfield, Illinois, 60015 June 6, 2005
Iboctadekin Renal cancer GlaxoSmithKline LLC;Corporation service Company, Suite 400;Wilmington, Delaware, 19808 June 3, 2005
Cytomegalovirus DNA vaccine with plasmids expressing pp65 and gB genes Prevention of clinically significant cytomegalovirus (CMV) viremia, CMV disease and associated complications in at-risk hematopoietic cell transplant and solid transplant populations Astellas Pharma Global Development, Inc.;1 Astellas Way;Northbrook, Illinois, 60062 June 3, 2005
Sodium phenylacetate/sodium benzoate 10%/10% Injection Hepatic encephalopathy Ucyclyd Pharma, Inc.;7720 N. Dobson Road;Scottsdale, Arizona, 85256 June 3, 2005
Digitoxin Cystic fibrosis Silver Pharmaceuticals;350 Seven Locks Road, Suite 211;Rockville, Maryland, 20854 May 27, 2005
Cilengitide Glioma EMD Serono, Inc.;One Technology Place;Rockland, Massachusetts, 02370 May 27, 2005
Titanium dioxide and bisoctrizole For the secondary prevention (prevention of lesional induction) of disorders with UV-A and visible light-induced photosensitivity, specifically Actinic prurigo, Hydroa vacciniforme, Solar urticara (SU), Chronic Actinic Dermatitis (CAD), the cutaneous prophyrias, Smith-Lemli-Optiz Syndrome, and Hartnup's Disease Orfagen;CRDPF - LANGLADE, 31035 Toulouse Cedex; May 25, 2005
Glyceryl tri (4-phenylbutyrate) Spinal muscular atrophy Ucyclyd Pharma, Inc;Subsidiary of Medicis Pharmaceutical Corporation, 7720 N. Dobson Road;Scottsdale, Arizona, 85256 May 24, 2005
Human anti-integrin receptor av monoclonal antibody Patients with angiosarcoma Janssen Research & Development, LLC;920 Route 202 South;Raritan, New Jersey, 08869 May 5, 2005
Recombinant human alpha 1-antitrypsin Bronchopulmonary dysplasia Arriva Pharmaceuticals, Inc.;1010 Atlantic Avenue;Alameda, California, 94501 April 28, 2005
L-threonyl-L-prolyl-L-prolyl-L-threonine Neuropathic pain associated with spinal cord injury Nyxis Neurotherapies, Inc.;1801 Maple Avenue, Suite 4300;Evanston, Illinois, 60201 April 26, 2005
Tramadol hydrochloride Management of postherpetic neuralgia TheraQuest Biosciences, LLC;146 Medinah Drive;Blue Bell, Pennsylvania, 19422 April 26, 2005