Treatments

The following database contains products that have been granted orphan status, or have been market approval in the EU or the USA.

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Country Product Indication Sponsor Date
Dimethylsulfoxide Topical treatment for the prevention of soft tissue injury following extravastion of cytotoxic drugs Cancer Technologies, Inc.;7301 East 22nd Street, Suite 10E;Tucson, Arizona, 85710 April 15, 1997
Levocarnitine Zidovudine-induced mitochondrial myopathy Leadiant Biosciences, Inc.;9841 Washingtonian Blvd, Suite 500;Gaithersburg, Maryland, 20878 April 7, 1997
MART-1 adenoviral gene therapy for malignant melanoma Metastatic melanoma Genzyme Corporation;500 Kendall Street;Cambridge, Massachusetts, 01701 March 28, 1997
Gp100 adenoviral gene therapy Metastatic melanoma Genzyme Corporation;500 Kendall Street;Cambridge, Massachusetts, 02142 March 25, 1997
Paclitaxel AIDS-related Kaposi's sarcoma Bristol-Myers Squibb Pharmaceutical Research Institute;5 Research Parkway, P.O. Box 5100;Wallingford, Connecticut, 06492 March 25, 1997
Beta alethine Metastatic melanoma Dovetail Technologies, Inc.;Bldg. 337, Paint Branch Drive;College Park, Maryland, 20742 March 24, 1997
8 Cyclopentyl 1,3-dipropylxanthine Cystic fibrosis SciClone Pharmaceuticals, Inc.;901 Mariner's Island Boulevard;San Mateo, California, 94404 March 24, 1997
Beta alethine Multiple myeloma Dovetail Technologies, Inc.;Bldg. 337, Paint Branch Drive;College Park, Maryland, 20742 March 24, 1997
Poly-ICLC Primary brain tumors Oncovir;3202 Cleveland Avenue N.W.;Washington, District of Columbia, 20008 March 17, 1997
Porfiromycin Cervical cancer Boehringer Ingelheim Pharmaceuticals, Inc.;900 Ridgebury Road, PO Box 368;Ridgefield, Connecticut, 06877 March 13, 1997
Chlorobutanol/propylene glycol/hydrochloric acid Patulous eustachian tube Ear Foundation;2420 Castillo Street, Suite 100;Santa Barbara, California, 93105 February 18, 1997
Lepirudin Heparin-associated thrombocytopenia type II Hoechst Marion Roussel;Frankfurt am Main, P.O. Box 1140;Marburg February 13, 1997
Dehydroepiandrosterone sulfate sodium Serious burns requiring hospitalization Pharmadigm, Inc.;2401 Foothill Drive;Salt Lake City, Utah, 84109 January 29, 1997
Dehydroepiandrosterone sulfate sodium To accelerate the re-epithelialization of donor sites in those hospitalized burn patients who must undergo autologous skin grafting Pharmadigm, Inc.;2401 Foothill Drive;Salt Lake City, Utah, 84109 January 28, 1997
Enadoline hydrochloride Severe head injury Warner-Lambert Company;Parke-Davis Pharmaceutical Research Division, 2800 Plymouth Road;Ann Arbor, Michigan, 48105 January 28, 1997
9-cis-retinoic acid Prevention of retinal detachment due to proliferative vitreoretinopathy Allergan, Inc.;2525 Dupont Drive, P.O. Box 19534;Irvine, California, 92623 January 2, 1997
Oprelvekin Prevention of severe chemotherapy-induced thrombocytopenia Genetics Institute, Inc.;87 Cambridge Park Drive;Cambridge, Massachusetts, 02140 December 17, 1996
Porcine fetal neural dopaminergic cells and/or precursors aseptically prepared and coated with anti-MHC-1 Ab for intracerebral implantation Hoehn and Yahr stage 4 and 5 Parkinson's disease Diacrin/Genzyme LLC;One Kendall Square;Cambridge, Massachusetts, 02129 December 17, 1996
Porcine fetal neural dopaminergic cells and/or precursors aseptically prepared for intracerebral implantation. Hoehn and Yahr stage 4 and 5 Parkinson's disease Diacrin/Genzyme LLC;One Kendall Square;Cambridge, Massachusetts, 02139 December 17, 1996
Nitazoxanide Cryptosporidiosis Romark Laboratories, L.C.;6200 Courtney Campbell Causeway, Suite 880;Tampa, Florida, 33607 December 12, 1996
Liposomal amphotericin B Histoplasmosis Fujisawa USA, Inc.;3 Parkway North Center;Deerfield, Illinois, 60015 December 10, 1996
Porcine fetal neural gabaergic cells and/or precursors aseptically prepared and coated with anti-MHC-1 Ab for intracerebral implantation Huntington disease Diacrin/Genzyme LLC;One Kendall Square;Cambridge, Massachusetts, 02129 December 10, 1996
Porcine fetal neural gabaergic cells and/or precursors aseptically prepared for intracerebral implantation for Huntington’s disease. Huntington disease Diacrin/Genzyme LLC;One Kendall Square;Cambridge, Massachusetts, 02139 December 10, 1996
N-acetyl-procainamide Prevention of life-threatening ventricular arrhythmias in patients with documented procainamide-induced lupus NAPA of the Bahamas;3560 Pennsylvania Avenue, Suite 7;Dubuque, Iowa, 52002 December 10, 1996
Liposomal amphotericin B Cryptococcal meningitis Fujisawa USA, Inc.;3 Parkway North Center;Deerfield, Illinois, 60015 December 10, 1996