SHANGHAI, China — GenFleet Therapeutics, a clinical-stage biotechnology company developing cutting-edge therapies in oncology and immunology, announced that U.S. Food and Drug Administration (FDA) has recently granted another two designations for SLS009 (GFH009). GFH009 (highly selective CDK9 inhibitor) so far has received both fast track and orphan drug designations from the...
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Tokyo, Japan – Researchers in the RIKEN Center for Brain Science (CBS) examined the genetics of autism spectrum disorder (ASD) by analyzing mutations in the genomes of individuals and their families. They discovered that a special kind of genetic mutation works differently from typical mutations in how it contributes to...
DANVILLE, Pa. – Genomic screening to identify hemochromatosis—a disorder that causes iron levels in the body to rise to dangerous levels—encourages people with the condition to seek treatment and ongoing management, a Geisinger study found. Hereditary hemochromatosis type 1 (HH1), caused by a change in the HFE gene, is underdiagnosed, often...
Tokyo, Japan – Researchers studied stomach and duodenal ulcers in a large research project comparing Japanese and European populations. They found 25 new genetic markers linked to ulcers which showed that, though these sores on the walls of the stomach and of the duodenum (the beginning part of the small...
Düsseldorf, Germany – Researchers from the German Diabetes Center (DDZ) and the Robert Koch Institute have discovered a law for the relationship between mortality and age in people with diabetes: According to this law, mortality in people with diabetes in Germany constantly rises by 8.3% in males and 10.2% in...
Bonn, Germany – Uveitis is a rare inflammatory eye disease. Posterior and panuveitis in particular are associated with a poor prognosis and a protracted course of the disease. Diagnosis and monitoring can be challenging for healthcare professionals. Fundus autofluorescence (FAF) is a fast and non-invasive imaging technique that supports this....
Meerbusch, Germany – Biologics are more effective at treating adult-onset Still’s disease (AOSD) than are glucocorticoids or conventional disease-modifying antirheumatic drugs (DMARDs), according to a new retrospective study. Half of the patients treated with first-line biologic DMARDs achieved sustained, event-free remission compared with 12% of patients in the conventional therapy...
Waltham, MA – A small study of 15 patients published Thursday in The New England Journal of Medicine provides strong evidence of the therapeutic potential of CD19 CAR-T therapies in autoimmune disorders. The study, conducted in Germany, enrolled patients who had been diagnosed with systemic lupus erythematosus (SLE), idiopathic inflammatory...
Barcelona, Spain – Researchers from the Germans Trias i Pujol Research Institute (IGTP) and the Barcelona Supercomputing Center-Centro Nacional de Supercomputación (BSC-CNS) have discovered new genetic mechanisms related to spinocerebellar ataxia type 37. Their research, published in the journal Human Genetics, employed advanced techniques such as CRISPR/Cas9 gene editing, real-time large DNA...
East Lansing, Michigan – Researchers at Michigan State University may have discovered why visceral pain is so common in people who have experienced inflammation in their guts, including patients with irritable bowel syndrome, or IBS. Working with mouse models, MSU physiologists showed that nervous system cells known as glia can...