COLUMBIA, Mo. ― Researchers from the University of Missouri School of Medicine found that a targeted gene therapy may make acute myeloid leukemia (AML) more sensitive to chemotherapy, while also protecting the heart against toxicity often caused by cancer treatments. Acute myeloid leukemia is the most common type of leukemia...
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About one in 100 children has a common brain disorder called Chiari 1 malformation, but most of the time such children grow up normally and no one suspects a problem. But in about one in 10 of those children, the condition causes headaches, neck pain, hearing, vision and balance disturbances,...
Göteborg, Sweden – Alzheimer’s disease (AD) is associated with damaging protein aggregates in the brain, with β-amyloid (Aβ) aggregates called plaques being the key pathology. Entresto (sacubitril/valsartan) is a combined neprilysin inhibitor and angiotensin receptor blocker, approved for the treatment of heart failure. Concerns were raised by the FDA that...
ASAN, South Korea – A widely used gout medication may offer a new therapeutic approach for Gaucher disease, according to a recent laboratory study that identified colchicine as a promising candidate for drug repurposing. Researchers found that colchicine, an oral anti-inflammatory drug approved for gout and certain cardiovascular conditions, significantly...
LEXINGTON, Mass. — Partner Therapeutics, Inc. (PTx) announced today the publication of a comprehensive review by Mora et al. in the International Journal of Cancer which summarizes the efficacy and safety of anti-GD2 monoclonal antibodies (mAbs) (dinutuximab, dinutuximab beta, and naxitamab) in children with high-risk neuroblastoma when given in combination with Leukine...
OSLO, Norway – Targovax ASA (OSE: TRVX), a clinical stage immuno-oncology company developing immune activators to target hard-to-treat solid tumors, today announces 21-month follow-up data from the randomized phase I/II trial of ONCOS-102 in combination with standard of care chemotherapy in malignant pleural mesothelioma (MPM). The trial is an open...
Ithaca, NY – Cornell University scientists have designed a way to “cloak” proteins in a generalized technique that could lead to repurposing things like antibodies for biological research and therapeutic applications. The “cloaked” proteins can be captured by lipid nanoparticles, which are akin to tiny bubbles of fat. These bubbles...
Changsha, China – New research published in Arthritis & Rheumatology suggests that for people overweight or with obesity who also have knee or hip osteoarthritis, a slow-to-moderate—but not fast—rate of weight loss caused by anti-obesity medications may lower their risk of premature death. Among 6,524 participants with knee or hip...
San Francisco, Calif. – A team of international research institutions, led by UC San Francisco, has completed the first large-scale study of posterior cortical atrophy, a baffling constellation of visuospatial symptoms that present as the first symptoms of Alzheimer’s disease. These symptoms occur in up to 10% of cases of...
Neurological diseases including Parkinson’s, Tourette’s, attention deficit hyperactivity disorder (ADHD), Alzheimer’s, and schizophrenia are all associated with alterations in dopamine-driven function involving the dopamine transporter (DAT). Research published today in the open access journal BMC Neuroscience suggests that a number of estrogens acting through their receptors affect the DAT, which...