Varna, Bulgaria – Melanoma is a fast-progressing skin cancer characterized by a high mortality rate after metastasis. Local chemotherapy could be considered a therapeutic approach only in stage 0 of progression (in situ melanoma) and in the postoperative phase after surgical removal of suspected skin lesions. For this purpose, drugs such...
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York, UK – Scientists have developed a new, safe and effective way to infect volunteers with the parasite that causes leishmaniasis and measure the body’s immune response, bringing a vaccine for the neglected tropical disease a step closer. The breakthrough, by a team from the University of York and Hull...
Zurich, Switzerland – Acute myeloid leukemia (AML) is an aggressive form of blood cancer. It is caused by mutations in a large number of genes that are acquired in the course of a person’s life. One of these genes – the tumor suppressor gene TP53 – plays a key role....
Zurich, Switzerland – CRISPR-Cas systems, which consist of protein and RNA components, originally developed as a natural defense mechanism of bacteria to fend off intruding viruses. Over the last decade, re-engineering these so-called “gene scissors” has revolutionized genetic engineering in science and medicine. The tools can be programmed to find...
SAN FRANCISCO, Calif. — Unlearn®, a leader in AI-powered solutions for clinical trials, today announced a collaboration with Trace Neuroscience, a biotechnology company focused on developing genomic therapies for neurodegenerative diseases. The partnership will support Trace Neuroscience as the company plans its upcoming Phase 1/2 clinical trial in amyotrophic lateral...
Chengdu, China – Dementia stands as one of the most significant global health challenges of the 21st century, with over 50 million individuals worldwide currently affected, a number projected to triple by 2050, reaching 152 million, due to global population aging. Alzheimer’s disease (AD) is the predominant cause of dementia,...
Beijing, China – Brain cancer is one of the most aggressive and life-threatening diseases, with glioblastoma (GBM) being the most common and deadliest type. Patients often experience debilitating symptoms, including headaches, seizures, memory loss, and personality changes, all of which drastically reduce quality of life. Despite progress in surgery, radiotherapy,...
Jerusalem, Israel – Professor Asaf Hellman and his research team at the Hebrew University-Hadassah Medical School have unveiled new findings in the realm of methylation-directed regulatory networks. Their study sheds light on the mechanisms governing the activation and suppression of mutation-driven disease genes, particularly in cases like glioblastoma, offering insights...
Tokyo, Japan – Autism spectrum disorder (ASD) is a complex neuropsychiatric condition, marked by diverse cognitive and sensorimotor challenges, difficulties with social communication, and distinct behavioral patterns. While genetic factors are known to play a role, the intricate mechanisms driving this condition remain elusive. Moreover, a unified and comprehensive theoretical...
Barcelona, Spain – Most mutations which cause disease by swapping one amino acid out for another do so by making the protein less stable, according to a massive study of human protein variants published today in the journal Nature. Unstable proteins are more likely to misfold and degrade, causing them...