Philadelphia, PA – Researchers from the University of Pennsylvania, Perelman School of Medicine, Gene Therapy Program, and Moderna, have shown that repeated administration of lipid nanoparticle-encapsulated mRNA therapy significantly extended survival and reduced serum leucine levels in a mouse model of maple syrup urine disease (MSUD). Click here to read...
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PHILADELPHIA, PA – When cells in the human body divide, they must first make accurate copies of their DNA. The DNA replication exercise is one of the most important processes in all living organisms and is fraught with risks of mutation, which can lead to cell death or cancer. Now,...
Pittsburgh, PA. – Researchers from the University of Pittsburgh have developed a new way to grow T cells in the lab that enables them to live longer and better destroy cancer cells in a mouse model of melanoma compared to those grown in traditional growth media. The findings, published recently...
PITTSBURGH, PA – A self-destructing vaccine administered intravenously provides additional safety and protection against tuberculosis (TB) in macaque monkeys, suggests new University of Pittsburgh research published today in Nature Microbiology. The in-built safety mechanisms circumvent the possibility of an accidental self-infection with weakened mycobacteria, offering a safe and effective way...
Brisbane, Australia – University of Queensland researchers have discovered a mechanism in DNA that regulates how disease-causing mutations are inherited. Dr Anne Hahn and Associate Professor Steven Zuryn from UQ’s Queensland Brain Institute said the findings could provide a promising therapeutic avenue to stop the onset of heritable and age-related...
Brisbane, Australia – University of Queensland researchers have identified an opportunity to reduce infections in people living with cystic fibrosis. Professor Matt Sweet, Dr Kaustav Das Gupta and Dr James Curson from UQ’s Institute for Molecular Bioscience have discovered a fault in the bacteria-killing function of immune cells in people...
Rochester, New York – Standard chemotherapy regimens, which are mostly based on testing in relatively young and healthy patients, may do more harm to older adults with cancer who often struggle with other health issues. New research, published yesterday in JAMA Network Open, shows that lowering the dose and adjusting...
Sharjah, United Arab Emirates – Scientists from the University of Sharjah say they have good news for breast cancer patients, particularly those afflicted with the most aggressive types of the malignant tumor known as triple-negative breast cancer. The study, published in the European Journal of Pharmacology, provides “new ways for...
Sheffield, England – Researchers at the University of Sheffield have discovered how a hospital superbug Clostridioides difficile (C.diff) can rapidly evolve resistance to vancomycin, the frontline drug used in the UK. Clostridioides difficile (C. diff), a type of bacteria which often affects people who have taken antibiotics, is responsible for approximately...
Los Angeles, CA – Cycles of a diet that mimics fasting can reduce signs of immune system aging, as well as insulin resistance and liver fat in humans, resulting in a lower biological age, according to a new USC Leonard Davis School of Gerontology-led study. The study, which appears in...