Ubiquitin is a small regulatory protein that has been found in almost all tissues of eukaryotic organisms.
Ubiquitin disorder is a newly discovered condition in which the spent protein isn’t flushed from the neurological cells by the ubiquitin system. The protein becomes a tangled mass that blocks the signal from the brain to the muscles, eventually affecting the use of the limbs, swallowing, speech, breathing and other bodily functions requiring muscles.
There are many other diseases where the ubiquitin pathway has been implicated in the pathogenesis:
neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS), Parkinsons Disease, and Alzheimers Disease; Angelman Syndrome; Von Hippel-Lyndau Syndrome; Fanconi Anemia; and 3M Syndrome to name a few.