Disease: Ubiquitin Disorder
- 18β-Glycyrrhetinic acid protects against deoxynivalenol-induced liver injury via modulating ferritinophagy and mitochondrial quality control
- 5-HT4 receptor agonists treatment reduces tau pathology and behavioral deficit in the PS19 mouse model of tauopathy
- A case of polyglucosan body myopathy caused by an RBCK1 gene variant and literature review
- A de novo dominant-negative variant is associated with OTULIN-related autoinflammatory syndrome
- A Novel PINK1 p.F385S Loss-of-Function Mutation in an Indian Family with Parkinson's Disease
- AlphaFold2 assists in providing novel mechanistic insights into the interactions among the LUBAC subunits
- An evolutionarily conserved ubiquitin ligase drives infection and transmission of flaviviruses
- An Overview of the Epigenetic Modifications in the Brain under Normal and Pathological Conditions
- ASB6 as an Independent Prognostic Biomarker for Colorectal Cancer Progression Involves Lymphatic Invasion and Immune Infiltration
- Association between Parkinson's Disease and Cancer: New Findings and Possible Mediators
- Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency
- Biomarker-based human and animal sperm phenotyping: the good, the bad and the ugly
- Breaking Bad Proteins-Discovery Approaches and the Road to Clinic for Degraders
- Cadmium contributes to cardiac metabolic disruption by activating endothelial HIF1A-GLUT1 axis
- Chemical tools to define and manipulate interferon-inducible Ubl protease USP18
- CircPDE5A-encoded novel regulator of the PI3K/AKT pathway inhibits esophageal squamous cell carcinoma progression by promoting USP14-mediated de-ubiquitination of PIK3IP1
- Clustered de novo start-loss variants in GLUL result in a developmental and epileptic encephalopathy via stabilization of glutamine synthetase
- COL5A1 promotes triple-negative breast cancer progression by activating tumor cell-macrophage crosstalk
- Combination of bone marrow mesenchymal stem cells and moxibustion restores cyclophosphamide-induced premature ovarian insufficiency by improving mitochondrial function and regulating mitophagy
- Cullin 3 RING E3 ligase inactivation causes NRF2-dependent NADH reductive stress, hepatic lipodystrophy, and systemic insulin resistance
- Decreased Ubiquitination and Acetylation of Histones 3 and 4 Are Associated with Obesity-Induced Disorders of Spermatogenesis in Mice
- DGS1 improves rice disease resistance by elevating pathogen-associated molecular pattern-triggered immunity
- Dissecting the effect of ALS mutation S375G on the conformational properties and aggregation dynamics of TDP-43<sub>370-375</sub> fragment
- DMT1 ubiquitination by Nedd4 protects against ferroptosis after intracerebral hemorrhage
- Dominant negative OTULIN-related autoinflammatory syndrome
- Dynamic molecular network analysis of iPSC-Purkinje cells differentiation delineates roles of ISG15 in SCA1 at the earliest stage
- E3 ubiquitin ligase NEDD4L negatively regulates skin tumorigenesis by inhibiting of IL-6/GP130 signaling pathway
- Echinococcus granulosus ubiquitin-conjugating enzymes (E2D2 and E2N) promote the formation of liver fibrosis in TGFbeta1-induced LX-2 cells
- Editorial: Regulation of hormone and growth factor signalling by ubiquitin and ubiquitin-like protein modifications
- Elongin B promotes breast cancer progression by ubiquitinating tumor suppressor p14/ARF
- Endothelial deubiquinatase YOD1 mediates Ang II-induced vascular endothelial-mesenchymal transition and remodeling by regulating β-catenin
- Enteric coronavirus nsp2 is a virulence determinant that recruits NBR1 for autophagic targeting of TBK1 to diminish the innate immune response
- Erratum to: Ubiquitin Specific Protease 13 Regulates Tau Accumulation and Clearance in Models of Alzheimer's Disease
- Extracellular vesicles containing circMYBL1 induce CD44 in adenoid cystic carcinoma cells and pulmonary endothelial cells to promote lung metastasis
- Ferroptosis and the ubiquitin-proteasome system: exploring treatment targets in cancer
- Further Characterization of the Antiviral Transmembrane Protein MARCH8
- Genetic diagnosis of endocrine disorders in Cyprus through the Cyprus Institute of Neurology and Genetics: an ENDO-ERN Reference Center
- Genetic overlap and causality between COVID-19 and multi-site chronic pain: the importance of immunity
- Gkongensin A, an HSP90β inhibitor, improves hyperlipidemia, hepatic steatosis, and insulin resistance
- Global profiling of protein S-palmitoylation in the second-generation merozoites of Eimeria tenella
- GSK3β and UCHL3 govern RIPK4 homeostasis via deubiquitination to enhance tumor metastasis in ovarian cancer
- HDAC6-dependent deacetylation of NGF dictates its ubiquitination and maintains primordial follicle dormancy
- High glutamine increases stroke risk by inducing the endothelial-to-mesenchymal transition in moyamoya disease
- How can we manage progressive supranuclear palsy syndrome with pharmacotherapy?
- Human neural stem cell secretome relieves endoplasmic reticulum stress-induced apoptosis and improves neuronal functions after traumatic brain injury in a rat model
- Identification and bioinformatics analysis of lncRNAs in serum of patients with ankylosing spondylitis
- Identification and validation of a costimulatory molecule-related signature to predict the prognosis for uveal melanoma patients
- Impaired malin expression and interaction with partner proteins in Lafora disease
- Improved therapeutic approach for spinal muscular atrophy via ubiquitination-resistant survival motor neuron variant
- Individual Atg8 paralogs and a bacterial metabolite sequentially promote hierarchical CASM-xenophagy induction and transition
- Inhibition of Immunoproteasome Attenuates NLRP3 Inflammasome Response by Regulating E3 Ubiquitin Ligase TRIM31
- Investigation of key miRNAs and Target-mRNA in Kaposi's sarcoma using bioinformatic methods
- Is There a Place for Lewy Bodies before and beyond Alpha-Synuclein Accumulation? Provocative Issues in Need of Solid Explanations
- Johanson-Blizzard Syndrome: A Case Report From Bahrain With a Literature Review
- Massive ER protein disposal by reticulophagy receptors and selective disposal by TOLLIP
- Mechanistic insights and the clinical prospects of targeted therapies for glioblastoma: a comprehensive review
- Mechanistic insights into the role of USP14 in adipose tissue macrophage recruitment and insulin resistance in obesity
- Mitochondrial import stress and PINK1-mediated mitophagy: the role of the PINK1-TOMM-TIMM23 supercomplex
- Multi-omics data-based analysis characterizes molecular alterations of the vesicle genes in human colorectal cancer
- Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells
- Notch1 hyperactivity drives ubiquitination of NOX2 and dysfunction of CD8+ regulatory T cells in patients with systemic lupus erythematosus
- Novel insights into the role of ubiquitination in osteoarthritis
- Nuclear speckle rejuvenation alleviates proteinopathies at the expense of YAP1
- O-GlcNAcylation promotes the progression of nonalcoholic fatty liver disease by upregulating the expression and function of CD36
- Parkinsonism Sac domain mutation in Synaptojanin-1 affects ciliary properties in iPSC-derived dopaminergic neurons
- PARP1 UFMylation ensures the stability of stalled replication forks
- Phage defence system CBASS is regulated by a prokaryotic E2 enzyme that imitates the ubiquitin pathway
- Post-translational modifications in kidney diseases and associated cardiovascular risk
- Post-Translational Modifications in Tau and Their Roles in Alzheimer's Pathology
- Predictive value of the hemispheric magnetic resonance angiography score on the development of indirect pial synangiosis after combined revascularization surgery for adult moyamoya disease
- Prevotella intermedia boosts OSCC progression through ISG15 upregulation: a new target for intervention
- Proteasome-Associated Syndromes: Updates on Genetics, Clinical Manifestations, Pathogenesis, and Treatment
- Proteasome-dependent degradation of histone H1 subtypes is mediated by its C-terminal domain
- Protein neddylation and its role in health and diseases
- Proteomic Analyses Reveal the Role of Alpha-2-Macroglobulin in Canine Osteosarcoma Cell Migration
- PTMs of PD-1/PD-L1 and PROTACs application for improving cancer immunotherapy
- Reading and Writing the Ubiquitin Code Using Genetic Code Expansion
- Reclassification of a spindle cell sarcoma after identification of a TFG-ROS1 fusion: A case demonstrating the clinical benefit of next-generation sequencing in sarcoma
- Research progress of PROTACs for neurodegenerative diseases therapy
- RNF31 alleviates liver steatosis by promoting p53/BNIP3-related mitophagy in hepatocytes
- Role of cyclophilin A in aggravation of myocardial ischemia reperfusion injury via regulation of apoptosis mediated by thioredoxin-interacting protein
- Sleep disturbance in Angelman syndrome patients
- Statins improve cardiac endothelial function to prevent heart failure with preserved ejection fraction through upregulating circRNA-RBCK1
- Targeting deubiquitinase OTUB1 protects vascular smooth muscle cells in atherosclerosis by modulating PDGFRβ
- Taurine activates the AKT-mTOR axis to restore muscle mass and contractile strength in human 3D in vitro models of steroid myopathy
- Tectorigenin protects against cardiac fibrosis in diabetic mice heart via activating the adiponectin receptor 1-mediated AMPK pathway
- The crosstalk between SUMOylation and immune system in host-pathogen interactions
- The E3 Ubiquitin Protein Ligase LINCR Amplifies the TLR-Mediated Signals through Direct Degradation of MKP1
- The F-box protein encoding genes of the leaf-rust fungi Puccinia triticina: genome-wide identification, characterization and expression dynamics during pathogenesis
- The significance of triple-capsid-mutant AAV8 for treatment of Sanfilippo Syndrome Type B
- Trametinib sensitizes KRAS-mutant lung adenocarcinoma tumors to PD-1/PD-L1 axis blockade via Id1 downregulation
- Transcriptome analysis of <em>Bipolaris sorokiniana</em> - <em>Hordeum vulgare</em> provides insights into mechanisms of host-pathogen interaction
- TRIM27-Induced Protective Autophagy: A Novel Therapeutic Approach for Pneumonia
- TRIM38 Induced in Respiratory Syncytial Virus-infected Cells Downregulates Type I Interferon Expression by Competing with TRIM25 to Bind RIG-I
- UBE2C: A pan-cancer diagnostic and prognostic biomarker revealed through bioinformatics analysis
- Ultrastructural localization of Porphyromonas gingivalis gingipains in the substantia nigra of Parkinson's disease brains
- Unveiling the clinical spectrum of relapsing polychondritis: insights into its pathogenesis, novel monogenic causes, and therapeutic strategies
- USP7 promotes cervical cancer progression by stabilizing MTDH expression through deubiquitination
- Variant-specific effects of GBA1 mutations on dopaminergic neuron proteostasis
- VEXAS syndrome: A new mimicker of idiopathic multicentric Castleman disease