• A clinical phenotype of VEXAS syndrome with pleural effusion, infiltrates, and systemic inflammation in a 76-year-old patient: a case report
• A novel lncRNA GM47544 modulates triglyceride metabolism by inducing ubiquitination-dependent protein degradation of APOC3
• A single amino acid substitution in the AAA-type ATPase LRD6-6 activates immune responses but decreases grain quality in rice
• A systematic exploration of unexploited genes for oxidative stress in Parkinson's disease
• AAV-mediated Stambp gene replacement therapy rescues neurological defects in a mouse model of microcephaly-capillary malformation syndrome
• ALDH2 deficiency augments atherosclerosis through the USP14-cGAS-dependent polarization of proinflammatory macrophages
• Alzheimer's disease risk gene CD2AP is a dose-sensitive determinant of synaptic structure and plasticity
• Analysis of the Upregulated Expression Mechanism of Apoptotic Chromatin Condensation Inducer 1 in Hepatocellular Carcinoma Based on Bioinformatics
• Angelman syndrome in Poland: current diagnosis and therapy status-the caregiver perspective: a questionnaire study
• Annexin A1 binds PDZ and LIM domain 7 to inhibit adipogenesis and prevent obesity
• ASB3 expression aggravates inflammatory bowel disease by targeting TRAF6 protein stability and affecting the intestinal microbiota
• BAP1-mediated MAFF deubiquitylation regulates tumor growth and is associated with adverse outcomes in colorectal cancer
• BRD4-specific PROTAC inhibits basal-like breast cancer partially through downregulating KLF5 expression
• Cardamonin intervenes in myocardial hypertrophy progression by regulating Usp18
• CircEZH2 promotes gallbladder cancer progression and lipid metabolism reprogramming through the miR-556-5p/SCD1 axis
• Clinicopathological and genetic characterization of radiotherapy-induced undifferentiated pleomorphic sarcoma following breast cancer: a case series of three tumors and comprehensive literature review
• Clitocine enhances the drug sensitivity of colon cancer cells by promoting FBXW7-mediated MCL-1 degradation via inhibiting the A2B/cAMP/ERK axis
• Comprehensive analysis identifies ubiquitin ligase FBXO42 as a tumor-promoting factor in neuroblastoma
• Comprehensive identification of ubiquitin-like 3 (UBL3)-interacting proteins in the mouse brain
• Crosstalk among Alternative Polyadenylation, Genetic Variants and Ubiquitin Modification Contribute to Lung Adenocarcinoma Risk
• Deficiency in the mitophagy mediator Parkin accelerates murine skin allograft rejection
• Deleterious ZNRF3 germline variants cause neurodevelopmental disorders with mirror brain phenotypes via domain-specific effects on Wnt/beta-catenin signaling
• DOT1L-mediated RAP80 methylation promotes BRCA1 recruitment to elicit DNA repair
• Dysfunction of Mitochondrial Dynamics Induces Endocytosis Defect and Cell Damage in <em>Drosophila</em> Nephrocytes
• FBXO22 promotes osteosarcoma progression via regulation of FOXO1 for ubiquitination and degradation
• FBXO24 deletion causes abnormal accumulation of membraneless electron-dense granules in sperm flagella and male infertility
• Gene editing of the E3 ligase PIRE1 fine-tunes ROS production for enhanced bacterial disease resistance in tomato
• Genetic Mutations Associated With TNFAIP3 (A20) Haploinsufficiency and Their Impact on Inflammatory Diseases
• GGC repeat expansions in NOTCH2NLC cause uN2CpolyG cerebral amyloid angiopathy
• Gubi decoction mitigates knee osteoarthritis via promoting chondrocyte autophagy through METTL3-mediated ATG7 m⁶A methylation
• Gut microbiota-derived indole-3-propionic acid alleviates diabetic kidney disease through its mitochondrial protective effect via reducing ubiquitination mediated-degradation of SIRT1
• Haplotype analysis identifies functional elements in monoclonal gammopathy of unknown significance
• Hereditary Colorectal Cancer and Polyposis Syndromes Caused by Variants in Uncommon Genes
• Incidence and characterization of polyglucosan bodies in the cerebella of montserrat orioles (<em>Icterus oberi</em>)
• Increase of PCSK9 expression in diabetes promotes VEGFR2 ubiquitination to inhibit endothelial function and skin wound healing
• Influenza A virus infection activates caspase-8 to enhance innate antiviral immunity by cleaving CYLD and blocking TAK1 and RIG-I deubiquitination
• Inhibition of SUMOylation Induces Adaptive Antitumor Immunity against Pancreatic Cancer through Multiple Effects on the Tumor Microenvironment
• Interplay of PROTAC Complex Dynamics for Undruggable Targets: Insights into Ternary Complex Behavior and Linker Design
• Iron-sulfur cluster loss in mitochondrial CISD1 mediates PINK1 loss-of-function phenotypes
• ITPKA phosphorylates PYCR1 and promotes the progression of glioma
• Kumujan B suppresses TNF-α-induced inflammatory response and alleviates experimental colitis in mice
• LAT1 expression in colorectal cancer cells is unresponsive to HIF-1/2α accumulation under experimental hypoxia
• Lys-63-specific deubiquitinase BRCC36 enhances the sensitivity of multiple myeloma cells to lenalidomide by inhibiting lysosomal degradation of cereblon
• Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex
• Mediastinal lymphadenopathy due to VEXAS syndrome
• Metabolomic and Proteomic Analyses to Reveal the Role of Plant-Derived Smoke Solution on Wheat under Salt Stress
• MiR-4769-3p suppresses adipogenesis in systemic sclerosis by negatively regulating the USP18/VDAC2 pathway
• Molecular signatures in Mendelian neurodevelopment: a focus on ubiquitination driven DNA methylation aberrations
• mTORC1 phosphorylates and stabilizes LST2 to negatively regulate EGFR
• Multi-regulatory potency of USP1 on inflammasome components promotes pyroptosis in thyroid follicular cells and contributes to the progression of Hashimoto's thyroiditis
• Neuronal UBE3A substrates hold therapeutic potential for Angelman syndrome
• NrCAM activates the NF-kappaB signalling pathway by competitively binding to SUMO-1 and promotes Th17 cell differentiation in Graves' disease
• Otilonium bromide ameliorates pulmonary fibrosis in mice through activating phosphatase PPM1A
• Overexpression of long noncoding RNA DUXAP8 inhibits ER-phagy through activating AKT/mTOR signaling and contributes to preeclampsia
• Paeoniflorin suppresses ferroptosis after traumatic brain injury by antagonizing P53 acetylation
• PARK2 as a susceptibility factor for nontuberculous mycobacterial pulmonary disease
• Peptide degrader-based targeting of METTL3/14 improves immunotherapy response in cutaneous melanoma
• Peripheral sequestration of huntingtin delays neuronal death and depends on N-terminal ubiquitination
• Porcine deltacoronavirus nucleocapsid protein interacts with the Grb2 through its proline-rich motifs to induce activation of the Raf-MEK-ERK signal pathway and promote virus replication
• Post-Translational Modifications Control The Signal At The Crossroads Of Plant-Pathogen Interaction
• Post-translational Modifications of α-Synuclein, their Therapeutic Potential and Crosstalk in Health and Neurodegenerative Diseases
• Potential Diagnostic Biomarkers of tRNA-Derived Small RNAs in PBMCs for Nonproliferative Diabetic Retinopathy in Patients With Type 2 Diabetes Mellitus
• Precision oncology revolution: CRISPR-Cas9 and PROTAC technologies unleashed
• Presynaptic neurons self-tune by inversely coupling neurotransmitter release with the abundance of CaV2 voltage-gated Ca²⁺ channels
• Rare genetic variants provide a mechanistic basis for immune imbalance in IgG4-related disease
• Recent insights of PROTAC developments in inflammation-mediated and autoimmune targets: a critical review
• Roles of TRIM21/Ro52 in connective tissue disease-associated interstitial lung diseases
• SARS-CoV-2 papain-like protease inhibits ISGylation of the viral nucleocapsid protein to evade host anti-viral immunity
• Serum and CSF biomarkers in asymptomatic patients during primary HIV infection: a randomized study
• Sleep disturbances associated with <em>DEAF1</em> pathogenic variants
• Stereoselective Bioactivity and Action Mechanism of the Fungicide Isopyrazam
• SUMOylation at the crossroads of gut health: insights into physiology and pathology
• Suppression of SENP3 enhances macrophage alternative activation by mediating IRF4 de-SUMOylation in ESCC progression
• TET3-overexpressing macrophages promote endometriosis
• The degradation of α--synuclein is limited by dynein to drive the AALP pathway through HDAC6 upon paraquat exposure
• The deubiquitinase BAP1 and E3 ligase UBE3C sequentially target IRF3 to activate and resolve the antiviral innate immune response
• The deubiquitinase USP15 drives malignant progression of gastric cancer through glucose metabolism remodeling
• The Deubiquitinase USP22-Stabilized COL17A1 Promotes Lung Adenocarcinoma Progression
• The E3 ligase TRIM22 functions as a tumor suppressor in breast cancer by targeting CCS for proteasomal degradation to inhibit STAT3 signaling
• The effector PHYL1_JWB from Candidatus Phytoplasma ziziphi induces abnormal floral development by destabilising flower development proteins
• The Fanconi anemia core complex promotes CtIP-dependent end resection to drive homologous recombination at DNA double-strand breaks
• The feedback loop between MTA1 and MTA3/TRIM21 modulates stemness of breast cancer in response to estrogen
• The new pattern for dual NOTCH pathway involving nuclear transcription and mitochondrial regulation supports therapeutic mechanism of 4-butyl benzophenone derivatives against SIRS
• The RING-finger ubiquitin E3 ligase TaPIR1 targets TaHRP1 for degradation to suppress chloroplast function
• The RING-Type E3 Ubiquitin Ligase Gene GhDIRP1 Negatively Regulates Verticillium dahliae Resistance in Cotton (Gossypium hirsutum)
• The Role of Deubiquitinating Enzymes in Primary Bone Cancer
• The role of protein post-translational modifications in prostate cancer
• Trends and Implications of Ribosome-associated Protein Quality Control in Diseases: A Bibliographic Analysis
• UBE2M forms a positive feedback loop with estrogen receptor to drive breast cancer progression and drug resistance
• Ubiquitin-specific protease 22 controls melanoma metastasis and vulnerability to ferroptosis through targeting SIRT1/PTEN/PI3K signaling
• Ubiquitin-specific protease 38 promotes atrial fibrillation in diabetic mice by stabilizing iron regulatory protein 2
• Ubiquitination of NS1 Confers Differential Adaptation of Zika Virus in Mammalian Hosts and Mosquito Vectors
• UBR1 promotes anaplastic thyroid carcinoma progression via stabilizing YAP through monoubiquitylation
• Unraveling neuroprotection in Parkinson's disease: Nrf2-Keap1 pathway's vital role amidst pathogenic pathways
• Unveiling the intracellular dynamics of α4β2 nAChR-mediated ERK activation through the interplay of arrestin, Gβγ, and PKCβII
• Urine-derived podocytes from steroid resistant nephrotic syndrome patients as a model for renal-progenitor derived extracellular vesicles effect and drug screening
• USP11 promotes renal tubular cell pyroptosis and fibrosis in UUO mice via inhibiting KLF4 ubiquitin degradation
• Usp14 down-regulation corrects sleep and circadian dysfunction of a Drosophila model of Parkinson's disease
• Uveal Melanoma Zebrafish Xenograft Models Illustrate the Mutation Status-Dependent Effect of Compound Synergism or Antagonism
• YAP O-GlcNAcylation contributes to corneal epithelial cell ferroptosis under cigarette smoke exposure