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• <em>Inonotus obliquus</em> upregulates muscle regeneration and augments function through muscle oxidative metabolism
• A Landmark Paper That Introduced Proteasome Inhibition in Myeloma
• A microprotein N1DARP encoded by LINC00261 promotes Notch1 intracellular domain (N1ICD) degradation via disrupting USP10-N1ICD interaction to inhibit chemoresistance in Notch1-hyperactivated pancreatic cancer
• A Rab-bit hole: Rab40 GTPases as new regulators of the actin cytoskeleton and cell migration
• A sorghum F-box protein induces an oxidative burst in the defense against Colletotrichum sublineola
• Active metabolites and potential mechanisms of <em>Notopterygium incisum</em> against obstructive sleep apnea Syndrome (OSAS): network analysis and experimental assessment
• Altered ubiquitin signaling induces Alzheimer's disease-like hallmarks in a three-dimensional human neural cell culture model
• BAP1 mutations inhibit the NF-κB signaling pathway to induce an immunosuppressive microenvironment in uveal melanoma
• BRWD3 promotes KDM5 degradation to maintain H3K4 methylation levels
• Changes in the Activities and Contents of Individual Forms of Proteasomes in Samples of the Cerebral Cortex during Pathology Development in 5xFAD Mice
• Chemical Specification of E3 Ubiquitin Ligase Engagement by Cysteine-Reactive Chemistry
• Chiisanoside Mediates the Parkin/ZNF746/PGC-1α Axis by Downregulating MiR-181a to Improve Mitochondrial Biogenesis in 6-OHDA-Caused Neurotoxicity Models In Vitro and In Vivo: Suggestions for Prevention of Parkinson's Disease
• Classical swine fever virus NS5A protein antagonizes innate immune response by inhibiting the NF-κB signaling
• Comprehensive comparative assessment of the Arabidopsis thaliana MLO2-CALMODULIN2 interaction by various in vitro and in vivo protein-protein interaction assays
• Comprehensive Genomic Analysis Stratified by KRAS Status in Patients with Pancreatic Adenocarcinoma and Its Prognostic Significance
• Conditional loss of Ube3d in the retinal pigment epithelium accelerates age-associated alterations in the retina of mice
• CSE reduces OTUD4 triggering lung epithelial cell apoptosis via PAI-1 degradation
• Deep learning on electronic medical records identifies distinct subphenotypes of diabetic kidney disease driven by genetic variations in the <em>Rho</em> pathway
• Defining E3 ligase-substrate relationships through multiplex CRISPR screening
• Diagnostic and therapeutic targeting of pathological tau proteins in neurodegenerative disorders
• Discovery of a Potent Deubiquitinase (DUB) Small Molecule Activity-based Probe Enables Broad Spectrum DUB Activity Profiling in Living Cells
• Discovery of Nedd4 auto-ubiquitination inhibitors
• DNA methyltransferase 3A induces the occurrence of oral submucous fibrosis by promoting the methylation of the von Hippel-Lindau
• DTX3L mediated ubiquitination of cGAS suppresses antitumor immunity in pancreatic cancer
• E3 Ubiquitin Ligases in Gammaherpesviruses and HIV: A Review of Virus Adaptation and Exploitation
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• Elucidation of E3 ubiquitin ligase specificity through proteome-wide internal degron mapping
• Epitope identification of a Lys63 linkage ubiquitin antibody by mass spectrometric epitope excision and extraction approaches
• Expanding CYLD protein in NF-κβ/TNF-α signaling pathway in response to Lactobacillus acidophilus in non-metastatic rectal cancer patients
• Exploring The "Misfolding Problem" by Systematic Discovery and Analysis of Functional-But-Degraded Proteins
• FBXL5 promotes lipid accumulation in alcoholic fatty liver disease by promoting the ubiquitination and degradation of TFEB
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• Function and mechanism of MCM8 in the development and progression of colorectal cancer
• Gain-of-function MYCN causes a megalencephaly-polydactyly syndrome manifesting mirror phenotypes of Feingold syndrome
• Genome-wide association study reveals HSF2, GJA1 and TRIM36 as susceptibility genes for preeclampsia: a community-based population study in Tianjin, China
• GPRASP1 loss-of-function links to arteriovenous malformations by endothelial activating GPR4 signals
• Harnessing UBR5 for targeted protein degradation of key transcriptional regulators
• Hepatocyte TIPE2 is a fasting-induced Raf-1 inactivator that drives hepatic gluconeogenesis to maintain glucose homeostasis
• HER2-selective and reversible tyrosine kinase inhibitor tucatinib potentiates the activity of T-DM1 in preclinical models of HER2-positive breast cancer
• High air humidity dampens salicylic acid pathway and NPR1 function to promote plant disease
• High plasma nesfatin-1 level in Chinese adolescents with depression
• Histological diagnosis of polyploidy discriminates an aggressive subset of hepatocellular carcinomas with poor prognosis
• HSP90 C-terminal domain inhibition promotes VDAC1 oligomerization via decreasing K274 mono-ubiquitination in Hepatocellular Carcinoma
• Hypoxia-induced long non-coding RNA LINC00460 promotes p53 mediated proliferation and metastasis of pancreatic cancer by regulating the miR-4689/UBE2V1 axis and sequestering USP10
• Hypoxia-inducible factor upregulation by roxadustat attenuates drug reward by altering brain iron homoeostasis
• Identification of candidate genes and chemicals associated with osteoarthritis by transcriptome-wide association study and chemical-gene interaction analysis
• Identification of potential biomarkers of myopia based on machine learning algorithms
• IFP35 aggravates Staphylococcus aureus infection by promoting Nrf2-regulated ferroptosis
• Implications of ubiquitination and the maintenance of replication fork stability in cancer therapy
• Induction of proteasomal activity in mammalian cells by lifespan-extending tRNA synthetase inhibitors
• Integrative analysis of multi-omics data reveals inhibition of RB1 signaling promotes apatinib resistance of hepatocellular carcinoma
• LAD1 promotes malignant progression by diminishing ubiquitin-dependent degradation of vimentin in gastric cancer
• LC-MS/MS metabolomic profiling of the protective butylphthalide effect in cerebral ischemia/reperfusion mice
• LINC00955 suppresses colorectal cancer growth by acting as a molecular scaffold of TRIM25 and Sp1 to Inhibit DNMT3B-mediated methylation of the PHIP promoter
• Macrophages in the Inflammatory Phase following Myocardial Infarction: Role of Exogenous Ubiquitin
• MBL-1 and EEL-1 affect the splicing and protein levels of MEC-3 to control dendrite complexity
• Metabolite Neu5Ac triggers SLC3A2 degradation promoting vascular endothelial ferroptosis and aggravates atherosclerosis progression in ApoE^-/-mice
• Mitochondrial degradation: Mitophagy and beyond
• Mitotic DNA synthesis in untransformed human cells preserves common fragile site stability via a FANCD2-driven mechanism that requires HELQ
• Musculoskeletal complications of Cushing syndrome
• Mycobacteria modulate SUMOylation to suppresses protective responses in dendritic cells
• No evidence for neuronal damage or astrocytic activation in cerebrospinal fluid of Neuro-COVID-19 patients with long-term persistent headache
• Nrf2-mediated therapeutic effects of dietary flavones in different diseases
• Outer Membrane Protein 25 of Brucella suppresses TLR-mediated expression of proinflammatory cytokines through degradation of TLRs and adaptor proteins
• Parkinson's disease-linked parkin mutation disrupts recycling of synaptic vesicles in human dopaminergic neurons
• Post-translational modifications in stress granule and their implications in neurodegenerative diseases
• RNF152 Suppresses Fatty Acid Oxidation and Metastasis of Lung Adenocarcinoma by Inhibiting IRAK1-Mediated AKR1B10 Expression
• Role of NFE2L1 in the Regulation of Proteostasis: Implications for Aging and Neurodegenerative Diseases
• Role of the tripartite motif-containing (TRIM) family of proteins in insulin resistance and related disorders
• Salidroside Ameliorates Ischemia/Reperfusion-Induced Human Cardiomyocyte Injury by Inhibiting the Circ_0097682/miR-671-5p/USP46 Pathway
• Secreted LRPAP1 binds and triggers IFNAR1 degradation to facilitate virus evasion from cellular innate immunity
• Serum tau protein elevation in migraine: a cross-sectional case-control study
• Sesamol serves as a p53 stabilizer to relieve rheumatoid arthritis progression and inhibits the growth of synovial organoids
• SIRT2 alleviated renal fibrosis by deacetylating SMAD2 and SMAD3 in renal tubular epithelial cells
• Small non-coding RNA profiling in patients with gastrointestinal cancer
• Spotlights on ubiquitin-specific protease 12 (USP12) in diseases: from multifaceted roles to pathophysiological mechanisms
• Structural Optimization of Decoy Oligonucleotide-Based PROTAC That Degrades the Estrogen Receptor
• Sublytic C5b-9 induces TIMP3 expression by glomerular mesangial cells via TRAF6-dependent KLF5 K63-linked ubiquitination in rat Thy-1 nephritis
• SUMOylation effects on neural stem cells self-renewal, differentiation, and survival
• Targeting cis-regulatory elements of FOXO family is a novel therapeutic strategy for induction of leukemia cell differentiation
• The accelerated organ senescence and proteotoxicity in thyrotoxicosis mice
• The emerging roles of MARCH8 in viral infections: A double-edged Sword
• The MEK-ERK-Egr-1 axis and its regulation in cardiovascular disease
• Tissue Transglutaminase: A Multifunctional and Multisite Regulator in Health and Disease
• Transcription factor E4F1 as a regulator of cell life and disease progression
• Transcriptome screening identifies TIPARP as an antiviral host factor against the Getah virus
• TRIM6: An Upregulated Biomarker with Prognostic Significance and Immune Correlations in Gliomas
• Tripartite motif containing 59 mediates protective anti-oxidative effects in intestinal injury through Nrf2 signaling
• TrkB inhibition of DJ-1 degradation promotes the growth and maintenance of cancer stem cell characteristics in hepatocellular carcinoma
• Tyrosine-Mutant AAV8 Vector Mediated Efficient and Safe Gene Transfer of Pigment Epithelium-Derived Factor to Mouse Lungs
• Ubiquitination detection techniques
• Ubiquitination of ASCL1 mediates CD47 transcriptional activation of the AKT signaling pathway, and glycolysis promotes osteogenic differentiation of hBMSCs
• UBL3 Interaction with α-Synuclein Is Downregulated by Silencing MGST3
• UNC-116 and UNC-16 function with the NEKL-3 kinase to promote axon targeting
• Unraveling the battle for lysine: A review of the competition among post-translational modifications
• USP47 inhibits m6A-dependent c-Myc translation to maintain regulatory T cell metabolic and functional homeostasis
• USP7 Inhibition Suppresses Neuroblastoma Growth via Induction of p53-Mediated Apoptosis and EZH2 and N-Myc Downregulation
• Yin Yang 1 promotes the neuroendocrine differentiation of prostate cancer cells via the non-canonical WNT pathway (FYN/STAT3)
• Zuojin pill improves chronic unpredictable stress-induced depression-like behavior and gastrointestinal dysfunction in mice via the theTPH2/5-HT pathway