VCRC Tissue Repository

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Brief Title

VCRC Tissue Repository

Official Title

VCRC Tissue Biorepository Collection Protocol

Brief Summary

      The purpose of this study is to collect existing tissue specimens from subjects enrolled in
      Vasculitis Clinical Research Consortium (VCRC) studies. Analysis of these tissue specimens
      and linked clinical data collected through VCRC studies may lead to the identification and
      development of a series of translational research projects. Results of these studies will
      provide vasculitis researchers with insight into the causes of these diseases and generate
      new ideas for diagnostic tests and therapies, and will be of great interest to the larger
      communities of researchers investigating vasculitis and other autoimmune, inflammatory, and
      vascular diseases.
    

Detailed Description

      Biopsy specimens collected as standard of care for these diseases will be retrieved and used
      in research. The most common biopsies performed are kidney, lung, skin, nerves, and vessels;
      however, other tissue is also of interest for the study. Biopsies are not performed as part
      of this protocol, rather we will request consent to collect biopsy specimens already
      collected under routine care.
    


Study Type

Observational


Primary Outcome

Identify genes that increase the risk of developing vasculitis


Condition

Aortitis



Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information



Estimated Enrollment

1000

Start Date

November 2016

Completion Date

September 2022

Primary Completion Date

September 2022

Eligibility Criteria

        Inclusion Criteria:

          -  A participant will be deemed eligible for this study if the participant is/was
             enrolled in another one of the VCRC observational/longitudinal protocols (5502, 5503,
             5504, 5505, 5506, 5507, 5563) and/or one of the VCRC interventional studies (5522,
             5523, 5526, 5527, or 5562).

        Exclusion Criteria:

          -  Inability to give informed consent (or their guardians in the case of children) and to
             sign the consent form.

          -  Unwilling to allow the use of their tissue for research.
      

Gender

All

Ages

N/A - N/A

Accepts Healthy Volunteers

No

Contacts

Peter A Merkel, MD, MPH, , [email protected]

Location Countries

Canada

Location Countries

Canada

Administrative Informations


NCT ID

NCT02967068

Organization ID

VCRC5511

Secondary IDs

U54AR057319

Responsible Party

Principal Investigator

Study Sponsor

University of Pennsylvania

Collaborators

 National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Study Sponsor

Peter A Merkel, MD, MPH, Study Chair, University of Pennsylvania


Verification Date

March 2021