Brief Title
VCRC Tissue Repository
Official Title
VCRC Tissue Biorepository Collection Protocol
Brief Summary
The purpose of this study is to collect existing tissue specimens from subjects enrolled in
Vasculitis Clinical Research Consortium (VCRC) studies. Analysis of these tissue specimens
and linked clinical data collected through VCRC studies may lead to the identification and
development of a series of translational research projects. Results of these studies will
provide vasculitis researchers with insight into the causes of these diseases and generate
new ideas for diagnostic tests and therapies, and will be of great interest to the larger
communities of researchers investigating vasculitis and other autoimmune, inflammatory, and
vascular diseases.
Detailed Description
Biopsy specimens collected as standard of care for these diseases will be retrieved and used
in research. The most common biopsies performed are kidney, lung, skin, nerves, and vessels;
however, other tissue is also of interest for the study. Biopsies are not performed as part
of this protocol, rather we will request consent to collect biopsy specimens already
collected under routine care.
Study Type
Observational
Primary Outcome
Identify genes that increase the risk of developing vasculitis
Condition
Aortitis
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Estimated Enrollment
1000
Start Date
November 2016
Completion Date
September 2022
Primary Completion Date
September 2022
Eligibility Criteria
Inclusion Criteria:
- A participant will be deemed eligible for this study if the participant is/was
enrolled in another one of the VCRC observational/longitudinal protocols (5502, 5503,
5504, 5505, 5506, 5507, 5563) and/or one of the VCRC interventional studies (5522,
5523, 5526, 5527, or 5562).
Exclusion Criteria:
- Inability to give informed consent (or their guardians in the case of children) and to
sign the consent form.
- Unwilling to allow the use of their tissue for research.
Gender
All
Ages
N/A - N/A
Accepts Healthy Volunteers
No
Contacts
Peter A Merkel, MD, MPH, , [email protected]
Location Countries
Canada
Location Countries
Canada
Administrative Informations
NCT ID
NCT02967068
Organization ID
VCRC5511
Secondary IDs
U54AR057319
Responsible Party
Principal Investigator
Study Sponsor
University of Pennsylvania
Collaborators
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Study Sponsor
Peter A Merkel, MD, MPH, Study Chair, University of Pennsylvania
Verification Date
March 2021