Treatment of Wegener’s Granulomatosis With Cyclophosphamide

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Brief Title

Treatment of Wegener's Granulomatosis With Cyclophosphamide

Official Title

Treatment of Wegener's Granulomatosis With Cyclophosphamide

Brief Summary

      The purpose of this protocol is to continue to treat patients with Wegener's granulomatosis
      who have already entered the study, and to treat new patients. The investigators will attempt
      to correlate the clinical response with specific immunosuppressive effects of drug
      administration. The investigators are accumulating data on the optimal duration and side
      effects of therapy.
    

Detailed Description

      The purpose of the protocol is to continue to treat patients with Wegener's granulomatosis
      who have already entered the study, and to treat new patients. The investigators will attempt
      to correlate the clinical response with specific immunosuppressive effects of drug
      administration. The investigators are accumulating data on the optimal duration and side
      effects of therapy.

      Age Range: greater than 1 year
    

Study Phase

Phase 2

Study Type

Interventional




Condition

Vasculitis

Intervention

cyclophosphamide


Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Drug

Estimated Enrollment

200

Start Date

February 1976

Completion Date

February 2002


Eligibility Criteria

        Patients greater than 1 year of age with the clinical and pathological diagnosis of WG
        whose illness presents a risk of permanent disability or death. Examples of processes that
        impart risk of permanent disability or death include: peripheral and central nervous system
        disease, cardiac involvement, glomerulonephritis, and vascular comprise of gastrointestinal
        organs.

        No women who are pregnant or intend to become pregnant.

        No patients who have known malignancies.

        Patients must be HIV negative.
      

Gender

All

Ages

N/A - N/A

Accepts Healthy Volunteers

No

Contacts

, , 

Location Countries

United States

Location Countries

United States

Administrative Informations


NCT ID

NCT00001155

Organization ID

760042

Secondary IDs

76-I-0042


Study Sponsor

National Institute of Allergy and Infectious Diseases (NIAID)


Study Sponsor

, , 


Verification Date

February 2002