Brief Title
Tilting of Radioactive Plaques After Initial Accurate Placement for Treatment of Uveal Melanoma
Official Title
Tilting of Radioactive Plaques After Initial Accurate Placement for Treatment of Uveal Melanoma
Brief Summary
Plaque radiotherapy is a common treatment for uveal melanoma. However, local failure has been reported in up to 20% of patients. We use intraoperative ultrasonography at plaque insertion and removal to evaluate plaque movement as a potential factor in local failure.
Detailed Description
Episcleral plaque radiotherapy is a common treatment for uveal melanoma and results in local tumor control in most cases. However, local failure has been reported in a substantial proportion of patients. Since local failure greatly increases the risk of metastatic death, identifying and correcting the causes of local treatment failure are of paramount importance. Poor plaque localization is an important contributing factor to local failure. With the aid of intraoperative ultrasonography, most malpositioned plaques can be identified and readjusted at the time of plaque insertion. However, little is known about plaque movement during the 4-5 days of brachytherapy, which could also contribute to local failure. To address this question, we perform intraoperative B-scan ultrasonography at the time of iodine-125 radioactive plaque insertion and removal in uveal melanoma patients.
Study Type
Interventional
Primary Outcome
Plaque tilt using intraoperative ultrasonography
Condition
Uveal Melanoma
Intervention
Intraoperative ultrasonography
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Procedure
Estimated Enrollment
175
Start Date
July 2000
Completion Date
July 2007
Primary Completion Date
July 2007
Eligibility Criteria
Inclusion Criteria: - All patients with uveal melanoma treated with brachytherapy Exclusion Criteria: - Ciliary melanoma
Gender
All
Ages
18 Years - N/A
Accepts Healthy Volunteers
No
Contacts
J W Harbour, MD, ,
Location Countries
United States
Location Countries
United States
Administrative Informations
NCT ID
NCT00459849
Organization ID
HRPO# 07-0092
Study Sponsor
Barnes Retina Institute
Study Sponsor
J W Harbour, MD, Principal Investigator, Washington University School of Medicine
Verification Date
May 2008