Study of the Activity of PD-1 Inhibitors in Metastatic Uveal Melanoma

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Brief Title

Study of the Activity of PD-1 Inhibitors in Metastatic Uveal Melanoma

Official Title

Study of the Activity of PD-1 Inhibitors in Metastatic Uveal Melanoma

Brief Summary

      Study of the activity of PD-1 inhibitors in metastatic uveal melanoma

Detailed Description

      The aim of the research is to study the activity of PD-1 inhibitors in patients with
      metastatic uveal melanoma and treated by Nivolumab and Pembrolizumab. These molecules have
      already received the authorities approvals. The data collected will be crucial for the
      understanding of the mechanism of PD-1 inhibitors and also for the futures studies.

Study Type

Observational

Primary Outcome

Response rate Data collection of the efficacity of PD-1 inhibitors

Secondary Outcome

 Exploration of PD-1 inhibitors biomarkers

Condition

Uveal Melanoma

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Estimated Enrollment

100

Start Date

November 2016

Completion Date

December 2019

Primary Completion Date

November 2019

Eligibility Criteria

        Inclusion Criteria:

          -  Patients with metastatic uveal melanoma

          -  Patients who received at least once injection of Nivolumab or Pembrolizumab in the
             case of the disease's treatment

        Exclusion Criteria:

          -  Antecedent of another evolutionary tumor pathology

Gender

All

Ages

N/A - N/A

Contacts

Manuel Rodrigues, MD, ,

Location Countries

France

Location Countries

France

Administrative Informations

NCT ID

NCT03964298

Organization ID

IC-2016-05

Responsible Party

Sponsor

Study Sponsor

Institut Curie

Study Sponsor

Manuel Rodrigues, MD, Study Director, Institut Curie

Verification Date

October 2019