The Use of B-type Natriuretic Peptide (BNP) to Predict Closure of a Patent Ductus Arteriosus (PDA) in Premature Infants

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Brief Title

The Use of B-type Natriuretic Peptide (BNP) to Predict Closure of a Patent Ductus Arteriosus (PDA) in Premature Infants


Brief Summary

      A patent ductus arteriosus (PDA) is associated with increased morbidity in premature infants.
      Standard indomethacin treatment is associated with intestinal and renal morbidity. B-type
      natriuretic peptide is elevated in significant PDAs. This study will determine whether BNP
      guided therapy could reduce doses of indomethacin.
    



Study Type

Interventional


Primary Outcome

Number of indomethacin doses given on study

Secondary Outcome

 rate of PDA ligation

Condition

Indomethacin Therapy

Intervention

Withhold standard INDO dose if BNP < 100 pg/ml


Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Procedure

Estimated Enrollment

60

Start Date

April 2004

Completion Date

March 2007


Eligibility Criteria

        Inclusion Criteria:

          -  Infants with echocardiographically confirmed PDA

          -  Infants determined by attending physician to require PDA closure

        Exclusion Criteria:

          -  infants with congenital hearts disease

          -  infants with creatinine value > 2.0
      

Gender

All

Ages

N/A - 4 Months

Accepts Healthy Volunteers

No

Contacts

D Sc Lim, MD, , 



Administrative Informations


NCT ID

NCT00500305

Organization ID

10946



Study Sponsor

University of Virginia


Study Sponsor

D Sc Lim, MD, Principal Investigator, University of Virginia


Verification Date

May 2018