Brief Title
The Impact of Platelet Functions on Spontaneous Ductal Closure in Preterm Infants
Official Title
The Impact of Platelet Count, Platelet Mass Index and Platelet Function Evaluated by Platelet Function Analyzer (PFA-100) on Spontaneous Ductal Closure in Preterm Infants
Brief Summary
Although thrombocytopenia has been reported as a risk factor for patent ductus arterioses, there is lack of data on the function of platelets in ductal closure. Information on functions of platelets in ductal closure may change the known model for ductus arterioses and may affect the treatment modalities.
Detailed Description
Patent ductus arterioses is a common problem which involves both pulmonary and cardiac outcomes in preterm infants. Although thrombocytopenia has been reported as a risk factor for patent ductus arterioses, there is lack of data on the function of platelets in ductal closure. The investigators aim to investigate the relation between thrombocytopenia and platelet functions in pathogenesis of spontaneous ductal closure. The investigators hypothesize that Information on functions of platelets in ductal closure may change the known model for ductus arterioses and may affect the treatment modalities.
Study Type
Observational
Primary Outcome
spontaneous ductal closure
Secondary Outcome
need for treatment
Condition
Patent Ductus Arterioses
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Estimated Enrollment
80
Start Date
December 2013
Completion Date
January 2015
Primary Completion Date
December 2014
Eligibility Criteria
Inclusion Criteria: - gestational age lower than 30 weeks and birth weight lower than 1500 g - obtained informed consent Exclusion Criteria: - any received medical treatment in first 2 days of life - death in first 2 days - patients who received any thrombocyte or fresh frozen plasma suspensions - any known genetic thrombocyte disorder in the family
Gender
All
Ages
N/A - 7 Days
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Contacts
Omer Erdeve, Professor, ,
Location Countries
Turkey
Location Countries
Turkey
Administrative Informations
NCT ID
NCT02010879
Organization ID
PDAPFA-100 TRIAL
Responsible Party
Principal Investigator
Study Sponsor
Ankara University
Study Sponsor
Omer Erdeve, Professor, Principal Investigator, Ankara University
Verification Date
April 2016