Stress-induced Vascular Dysfunction: Evaluation of Endothelial Function in a Cohort of Patients With Takotsubo Syndrome

Brief Title

Stress-induced Vascular Dysfunction: Evaluation of Endothelial Function in a Cohort of Patients With Takotsubo Syndrome

Official Title

Stress-induced Vascular Dysfunction: Evaluation of Endothelial Function in a Cohort of Patients With Takotsubo Syndrome

Brief Summary

      The aim of this prospective single-center study is to evaluate endothelial function, arterial
      compliance, sympathetic nervous activity at rest and after mental and physical stress,
      carotid atherosclerosis, oxidative stress parameters, quality of life and platelet adhesion
      in patients with apical ballooning syndrome and age-matched controls.
    

Detailed Description

      The aim of this prospective single-center study is to evaluate endothelial function, arterial
      compliance, sympathetic nervous activity at rest and after mental and physical stress,
      carotid atherosclerosis, oxidative stress parameters, quality of life and platelet adhesion
      in patients with Takotsubo Syndrome (apical ballooning syndrome/broken heart syndrome) and
      age-matched controls.
    


Study Type

Observational


Primary Outcome

Endothelial function as flow mediated dilatation

Secondary Outcome

 Evaluation of vascular compliance as pulse wave analysis

Condition

Takotsubo Syndrome

Intervention

blood sample analysis


Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Procedure

Estimated Enrollment

44

Start Date

November 2010

Completion Date

October 2012

Primary Completion Date

October 2012

Eligibility Criteria

        Inclusion criteria: We plan to include male or female subjects, age 18-80 with a diagnosis
        of Takotsubo Syndrome (according to standard clinical criteria[Strony, J., et al., Analysis
        of shear stress and hemodynamic factors in a model of coronary artery stenosis and
        thrombosis. Am J Physiol, 1993. 265(5 Pt 2): p. H1787-96.]) in the last 10 years.

        Moreover, patients matched to the Takotsubo patients for age and cardiovascular risk
        factors will be included in the control group.

        All patients will signed an written informed consent

        Exclusion criteria:

          -  Long acting nitrates, or PDE-5-Hemmer

          -  Alcohol or drug abuse,

          -  Malignancy (unless healed or remission > 5 years)

          -  Disease with systemic inflammation (e.g. rheumatoid arthritis, M. Crohn)

          -  Pulmonary Hypertension

          -  Participation in another study within the last month
      

Gender

All

Ages

18 Years - 80 Years

Accepts Healthy Volunteers

No

Contacts

Georg Noll, Prof MD, , 

Location Countries

Switzerland

Location Countries

Switzerland

Administrative Informations


NCT ID

NCT01249599

Organization ID

2010-0210/1


Responsible Party

Sponsor

Study Sponsor

University of Zurich


Study Sponsor

Georg Noll, Prof MD, Principal Investigator, University Hospital Zurich, Division of Cardiology


Verification Date

December 2012