Schistosomiasis in Senegal

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Brief Title

Schistosomiasis in Senegal

Official Title

EID: Using Community Ecology Theory to Predict the Effects of Agricultural Expansion and Intensification on Infections of Humans: Implications for Sustainable Agriculture

Brief Summary

      Schistosomiasis is a flatworm transmitted from freshwater snails to humans in the tropics. In
      addition to this infectious disease, tropical developing countries are faced with
      malnutrition. We propose to alter pesticide and compost use to reduce schistosomiasis and
      maintain or even improve crop production.
    

Detailed Description

      We propose two types of manipulations. Bottom-up manipulations will affect snail resources,
      whereas top-down manipulations will affect snail predators. For the bottom-up manipulations,
      we will clear shistosoma infections in school children, then remove the primary habitat for
      snails, the submerged macrophyte Ceratophyllum demersum (with proper unmanipulated controls),
      compost it, apply it to crops, and then quantify reinfection rates and crop yields. The
      second bottom-up manipulation will be to clear shistosoma infections in school children,
      apply three agrochemical treatments (status quo control, shift to lower risk herbicides, or
      eliminate herbicides and fertilizers), and then quantify reinfection rates and crop yields.
      Farmers will be compensated for any loss in yields. For the top-down manipulations, every
      village will receive prawns that depredate snails. We will clear shistosoma infections in
      school children, apply three agrochemical treatments (status quo control, shift to lower risk
      insecticides that don't kill prawns, or eliminate insecticides), and then quantify
      reinfection rates and crop yields. Farmers will be compensated for any loss in yields.
    


Study Type

Interventional


Primary Outcome

Schistosomiasis reinfection rate

Secondary Outcome

 Crop yields

Condition

Schistosomiasis

Intervention

Bottom-up intervention

Study Arms / Comparison Groups

 Status quo
Description:  Status quo pesticide use

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Other

Estimated Enrollment

1477

Start Date

January 2, 2017

Completion Date

June 2021

Primary Completion Date

June 2021

Eligibility Criteria

        Inclusion Criteria:

          -  School age children

        Exclusion Criteria:

          -  Non-school age children
      

Gender

All

Ages

5 Years - 17 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Contacts

Jason R Rohr, PhD, , 

Location Countries

Senegal

Location Countries

Senegal

Administrative Informations


NCT ID

NCT03187366

Organization ID

R01TW010286


Responsible Party

Sponsor

Study Sponsor

University of Notre Dame

Collaborators

 Biomedical Research Center EPLS

Study Sponsor

Jason R Rohr, PhD, Principal Investigator, University of South Florida, Department of Integrative Biology


Verification Date

May 2020