Brief Title
Iron Supplementation in Schistosomiasis and Soil Transmitted Helminths Control Programmes in Zambia
Official Title
Iron Supplementation in Schistosomiasis and Soil Transmitted Helminths Control Programmes in Zambia
Brief Summary
The objectives of this study is:
- to establish the coverage rate of weekly iron supplementation in children in
intervention schools over a period of nine months
- document any side effects of weeekly iron supplementation among children in intervention
schools over a period of nine months asses the feasibility of incorporating the weekly
iron supplementation programme into the normal school activity in intervention schools
determine the extent of acceptability and support for the iron supplementation programme
by staff at the health centre nearest to the intervention schools
- compare the praziquantel efficacy and schistosomiasis reinfection in children in
intervention schools with that of children in control schools following the introduction
of weekely iron supplementation over a period of nine months
- determine the impact of weekly iron supplementation on haemoglobin levels of children in
intervention schools and compare with children in control schools over a period of nine
months
Detailed Description
Iron deficiency anaemia is a common denominator for both schistosomiasis and soil transmitted
helminths. Iron deficiency appears to affect the immune response against schistosomes and
intestinal helminths. It therefore follows that correcting the iron deficiency anaemia will
improve the efficacy of anthelminthics such as praziquantel (against schistosomiasis) and
albendazol (against soil transmitted helminths) and ability of the host immune system to
resist reinfection with schistosomes and soil transmitted helminths.
The aim of this study is to identify factors necessary for a successful weekly iron
supplementation programme in schistosomiasis and soil transmitted helminths control
programmes. In addition impact of weekly iron supplementation programme n haemoglobin levels,
efficacy of praziquantel, and schistosomiasis re-infection will be studied.
Study Type
Interventional
Primary Outcome
Urine samples examined for schistsoma haematobium at month 0, 3. 6 and 9
Secondary Outcome
Any side effects to iron supplementation, measured every week for the first foru weeks after treatment start. Mesured on:
Condition
Schistosomiasis
Intervention
ferrous sulphate (drug)
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Drug
Estimated Enrollment
480
Start Date
September 2005
Completion Date
April 2006
Eligibility Criteria
Inclusion Criteria:all schoolchildren, in grade 2 and 3, at four selected schools -
Exclusion Criteria:
-
Gender
All
Ages
9 Years - 15 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Contacts
Victor Mwanakasale, Ph.d.,M.Sc., ,
Location Countries
Zambia
Location Countries
Zambia
Administrative Informations
NCT ID
NCT00276224
Organization ID
SRP-ZM-VM-04
Study Sponsor
DBL -Institute for Health Research and Development
Study Sponsor
Victor Mwanakasale, Ph.d.,M.Sc., Principal Investigator, Tropical Disease Research Centre, Ndola, Zambia
Verification Date
October 2007