Brief Title
Repetitive Transcranial Magnetic Stimulation for the Treatment of the Tardive Dyskinesia.
Official Title
Repetitive Transcranial Magnetic Stimulation for the Treatment of the Tardive Dyskinesia.
Brief Summary
The purpose of this study is to explore the therapeutic effect and mechanism of transcranial
magnetic stimulation (rTMS) in the treatment of the tardive dyskinesia.
Detailed Description
The study was a parallel control design trial for 2 weeks. Patients with schizophrenia were
treated with 10-Hz rTMS on left motor cortex (added to the ongoing treatment). Clinical
symptoms and MEP were assessment before and after rTMS treatment.
Study Type
Interventional
Primary Outcome
Change from baseline in motor evoked potential(MEP)
Secondary Outcome
Change from baseline in cortical silent period
Condition
Tardive Dyskinesia
Intervention
Repetitive Transcranial Magnetic Stimulation
Study Arms / Comparison Groups
tardive dyskinesia group
Description: tardive dyskinesia group will be delivered at an intensity that is 80% of the resting motor threshold (RMT). Stimulation will be delivered at 10 Hz with 60 stimulation trains of 30 stimuli each (i.e., 1800 stimuli) and an intertrain interval of 12 sec in primary motor cortex（M1）.
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Device
Estimated Enrollment
60
Start Date
September 2016
Completion Date
December 2018
Primary Completion Date
December 2018
Eligibility Criteria
Inclusion Criteria:
- The diagnosis of schizophrenia according to DSM-IV；
- At least two item of Abnormal Involuntary Movement Scale（AIMS） must be 2 points or
higher
- these symptoms are not from Parkinson，tourette's syndrome,huntington disease
- Signed an informed consent
Exclusion Criteria:
- rTMS contraindications: intracranial metal substance, with heart pacemakers and
cochlear implants, intracranial pressure
- patients to be diagnosed according to DSM-IV for substance abused, development delayed
- current treatment with anticonvulsant acting drugs such as anticonvulsants,
benzodiazepines
- Acute risk of suicide and impulse
- history of epileptic seizures or the presence of epileptic activity documented on the
basis of EEG
- pregnant and lactant women
Gender
All
Ages
18 Years - 65 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Contacts
, +86 21 64387250-73775, [email protected]
Location Countries
China
Location Countries
China
Administrative Informations
NCT ID
NCT02840760
Organization ID
15ZR1435600
Responsible Party
Sponsor
Study Sponsor
Shanghai Mental Health Center
Study Sponsor
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Verification Date
June 2017