Repetitive Transcranial Magnetic Stimulation for the Treatment of the Tardive Dyskinesia.

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Brief Title

Repetitive Transcranial Magnetic Stimulation for the Treatment of the Tardive Dyskinesia.

Official Title

Repetitive Transcranial Magnetic Stimulation for the Treatment of the Tardive Dyskinesia.

Brief Summary

      The purpose of this study is to explore the therapeutic effect and mechanism of transcranial
      magnetic stimulation (rTMS) in the treatment of the tardive dyskinesia.
    

Detailed Description

      The study was a parallel control design trial for 2 weeks. Patients with schizophrenia were
      treated with 10-Hz rTMS on left motor cortex (added to the ongoing treatment). Clinical
      symptoms and MEP were assessment before and after rTMS treatment.
    


Study Type

Interventional


Primary Outcome

Change from baseline in motor evoked potential(MEP)

Secondary Outcome

 Change from baseline in cortical silent period

Condition

Tardive Dyskinesia

Intervention

Repetitive Transcranial Magnetic Stimulation

Study Arms / Comparison Groups

 tardive dyskinesia group
Description:  tardive dyskinesia group will be delivered at an intensity that is 80% of the resting motor threshold (RMT). Stimulation will be delivered at 10 Hz with 60 stimulation trains of 30 stimuli each (i.e., 1800 stimuli) and an intertrain interval of 12 sec in primary motor cortex(M1).

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Device

Estimated Enrollment

60

Start Date

September 2016

Completion Date

December 2018

Primary Completion Date

December 2018

Eligibility Criteria

        Inclusion Criteria:

          -  The diagnosis of schizophrenia according to DSM-IV;

          -  At least two item of Abnormal Involuntary Movement Scale(AIMS) must be 2 points or
             higher

          -  these symptoms are not from Parkinson,tourette's syndrome,huntington disease

          -  Signed an informed consent

        Exclusion Criteria:

          -  rTMS contraindications: intracranial metal substance, with heart pacemakers and
             cochlear implants, intracranial pressure

          -  patients to be diagnosed according to DSM-IV for substance abused, development delayed

          -  current treatment with anticonvulsant acting drugs such as anticonvulsants,
             benzodiazepines

          -  Acute risk of suicide and impulse

          -  history of epileptic seizures or the presence of epileptic activity documented on the
             basis of EEG

          -  pregnant and lactant women
      

Gender

All

Ages

18 Years - 65 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Contacts

, +86 21 64387250-73775, [email protected]

Location Countries

China

Location Countries

China

Administrative Informations


NCT ID

NCT02840760

Organization ID

15ZR1435600


Responsible Party

Sponsor

Study Sponsor

Shanghai Mental Health Center


Study Sponsor

, , 


Verification Date

June 2017