D-Serine Treatment For Tardive Dyskinesia

Learn more about:
Related Clinical Trial
A Dose-escalation Study to Evaluate the Safety, Tolerability and Pharmacokinetic of LPM3770164 in Healthy Subjects Reduction of Demoralization After Treatment of TD With Valbenazine Efficacy Study of Panax Ginseng to Boost Antipsychotics Effects in Schizophrenia The Potential for Clinical Dependence and Withdrawal Symptoms Associated With Valbenazine Dysport for the Treatment of OMD Validation of the Implantation of a New Electrode for the Treatment of Dystonia Smoking Cessation With Varenicline in Schizophrenia: Antipsychotic-Induced Neurological Symptoms as Correlates Safety and Tolerability Study of NBI-98854 for the Treatment of Tardive Dyskinesia Randomized Controlled Trial of Pyridoxine for Tardive Dyskinesia D-Serine Treatment For Tardive Dyskinesia Deep Brain Stimulation for Patients With Tardive Dyskinesia and or Dystonia Persistence of Effect and Safety of Valbenazine for the Treatment of Tardive Dyskinesia Levetiracetam Treatment of Tardive Dyskinesia The Assessment of Movement Disorders Utilizing Live Two-Way Video Real‐World Evaluation Screening Study and Registry of Dyskinesia in Patients Taking Antipsychotic Agents Xenazine in Late Dyskinetic Syndrome With Neuroleptics Safety and Efficacy of Propranolol in the Treatment of Tardive Dyskinesia Effect of tDCS on Cognition, Symptoms in Chronic Schizophrenia Patients With Tardive Dyskinesia Melatonin Treatment for Tardive Dyskinesia in Schizophrenia Extract of Ginkgo Biloba and Tardive Dyskinesia Aim to Reduce Movements in Tardive Dyskinesia Reducing Involuntary Movements in Tardive Dyskinesia A Phase 3 Study of NBI-98854 for the Treatment of Tardive Dyskinesia NBI-98854 Dose Titration Study for the Treatment of Tardive Dyskinesia Pyridoxal Kinase Activity in Tardive Dyskinesia Rollover Study for Continuing Valbenazine (NBI-98854) Administration for the Treatment of Tardive Dyskinesia NBI-98854 for the Treatment of Tardive Dyskinesia in Subjects With Schizophrenia or Schizoaffective Disorder (KINECT Study) NBI-98854 for the Treatment of Tardive Dyskinesia in Subjects With Schizophrenia or Schizoaffective Disorder Repetitive Transcranial Magnetic Stimulation for the Treatment of the Tardive Dyskinesia. Efficacy and Safety of NBI-98854 in Subjects With Tardive Dyskinesia Efficacy and Safety of MT-5199 in Subjects With Tardive Dyskinesia Piracetam for Treatment Tardive Dyskinesia Treatment of Tardive Dyskinesia With Galantamine Tardive Dyskinesia and Cognitive Function Safety and Efficacy of Pyridoxal 5′ -Phosphate in the Treatment of Tardive Dyskinesia Addressing Involuntary Movements in Tardive Dyskinesia Efficacy of Docosahexaenoic Acid on Tardive Dyskinesia

Brief Title

D-Serine Treatment For Tardive Dyskinesia

Official Title


Brief Summary

      Presently no generally effective treatments for tardive dyskinesia (TD) are available.
      D-serine is a naturally occurring amino acid that acts in-vivo as positive allosteric
      modulator at the glycine site associated with the glutamatergic NMDA receptor. Previous
      studies have suggested that D-serine may improve motor symptoms, including dyskinesias, which
      are caused by treatment with presently used antipsychotics drugs.

      The hypothesis under investigation in the present study is that D-serine adjuvant treatment
      may improve TD in schizophrenia patients diagnosed with this disorder.

Study Type


Primary Outcome

Change in AIMS total score


Schizophrenia and Schizoaffective Disorder



Study Arms / Comparison Groups

 D-serine adjuvant treatment
Description:  Random assignment, parallel group, double blind, placebo controlled 8 weeks trial.
First arm: D-serine adjuvant treatment, up to 4 g/day Second arm: Placebo adjuvant treatment


* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status

Dietary Supplement

Estimated Enrollment


Start Date

January 2013

Completion Date

January 2019

Primary Completion Date

January 2019

Eligibility Criteria

        Inclusion Criteria:

          1. age 18-70;

          2. diagnosis of schizophrenia/schizoaffective disorder according to DSM-IV criteria;
             diagnosis will be made on the basis of SCID interview and information from medical
             records, previous treating psychiatrists, and family informants;

          3. history of ≥3 months antipsychotic drugs treatment and present stable dose
             antipsychotic treatment for at last 4 weeks;

          4. fulfillment of Schooler-Kane TD research criteria on a first evaluation performed 2-12
             weeks prior to study entrance and on a subsequent evaluation performed prior to
             allocation to experimental treatment.

        Exclusion Criteria:

          1. meeting criteria for other DSM-IV Axis I diagnoses;

          2. presence of a neurological disorder or history of significant head injury;

          3. substance abuse or alcoholism during entire lifetime;

          4. are judged clinically to be at suicidal or homicidal risk;

          5. female patients who are pregnant or lactating; female patients who are not pregnant or
             lactating, if sexually active, must be using medically accepted means of




18 Years - 70 Years

Accepts Healthy Volunteers



Uriel Heresco-Levy, MD, , 

Location Countries


Location Countries


Administrative Informations



Organization ID


Responsible Party

Principal Investigator

Study Sponsor

Herzog Hospital

Study Sponsor

Uriel Heresco-Levy, MD, Principal Investigator, Herzog Hospital

Verification Date

October 2018