Brief Title
Pulmonary Artery Involvement in Takayasu's Arteritis
Official Title
Pulmonary Artery Involvement in Takayasu's Arteritis: a Retrospective Study in China
Brief Summary
The purpose of this study is to analyze the clinical manifestations, imaging features, and prognosis-related factors of pulmonary artery (PA) involvement in Takayasu's arteritis (TA), and to explore the early clinical features of PA involvement in TA patients.
Detailed Description
Takayasu's arteritis patients with pulmonary artery involvement were enrolled into this study. The demographic information of the patients (age, sex, course of disease), symptoms at their admissions (cough, hemoptysis, dyspnea, palpitations, fever), laboratory examinations (blood lab routines, erythrocyte sedimentation rate, C-reactive protein), and imaging examinations (vascular ultrasonography, computed tomographic angiography, echocardiography, chest CT, CTPA, pulmonary perfusion imaging, pulmonary angiography, PET/CT) were collected by reviewing the cases. The prognostic information was collected by telephone follow-up. The follow-up end point was December 2015.
Study Type
Observational
Primary Outcome
Pulmonary Artery Systolic Blood Pressure
Condition
Takayasu Arteritis
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Estimated Enrollment
51
Start Date
January 1, 2014
Completion Date
December 31, 2015
Primary Completion Date
December 31, 2015
Eligibility Criteria
Inclusion Criteria: - 1.Meet the diagnostic criteria of TA as defined by the American College of Rheumatology (ACR). - 2.PA involvement: meet at least one of three items: (1) at least one of computed tomographic pulmonary angiography (CTPA), pulmonary perfusion imaging, or pulmonary arteriography suggests thickening of vessel wall, stenosis, aneurysm, or occlusion; (2) 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) suggests high intake of local radioactive material in pulmonary artery wall; (3) pulmonary artery systolic blood pressure is higher than 50 mmHg assessed by transthoracic echocardiography (defined as PAH), without left ventricular disease. Exclusion Criteria: -
Gender
All
Ages
14 Years - 67 Years
Accepts Healthy Volunteers
No
Contacts
Juhong Shi, M.D, ,
Location Countries
China
Location Countries
China
Administrative Informations
NCT ID
NCT03189602
Organization ID
PUMCH-Pulmonary arteritis
Responsible Party
Sponsor
Study Sponsor
Peking Union Medical College Hospital
Study Sponsor
Juhong Shi, M.D, Study Chair, Peking Union Medical College Hospital
Verification Date
June 2017