Pulmonary Artery Involvement in Takayasu’s Arteritis

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Brief Title

Pulmonary Artery Involvement in Takayasu's Arteritis

Official Title

Pulmonary Artery Involvement in Takayasu's Arteritis: a Retrospective Study in China

Brief Summary

      The purpose of this study is to analyze the clinical manifestations, imaging features, and
      prognosis-related factors of pulmonary artery (PA) involvement in Takayasu's arteritis (TA),
      and to explore the early clinical features of PA involvement in TA patients.

Detailed Description

      Takayasu's arteritis patients with pulmonary artery involvement were enrolled into this
      study. The demographic information of the patients (age, sex, course of disease), symptoms at
      their admissions (cough, hemoptysis, dyspnea, palpitations, fever), laboratory examinations
      (blood lab routines, erythrocyte sedimentation rate, C-reactive protein), and imaging
      examinations (vascular ultrasonography, computed tomographic angiography, echocardiography,
      chest CT, CTPA, pulmonary perfusion imaging, pulmonary angiography, PET/CT) were collected by
      reviewing the cases. The prognostic information was collected by telephone follow-up. The
      follow-up end point was December 2015.

Study Type


Primary Outcome

Pulmonary Artery Systolic Blood Pressure


Takayasu Arteritis


* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Estimated Enrollment


Start Date

January 1, 2014

Completion Date

December 31, 2015

Primary Completion Date

December 31, 2015

Eligibility Criteria

        Inclusion Criteria:

          -  1.Meet the diagnostic criteria of TA as defined by the American College of
             Rheumatology (ACR).

          -  2.PA involvement: meet at least one of three items: (1) at least one of computed
             tomographic pulmonary angiography (CTPA), pulmonary perfusion imaging, or pulmonary
             arteriography suggests thickening of vessel wall, stenosis, aneurysm, or occlusion;
             (2) 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT)
             suggests high intake of local radioactive material in pulmonary artery wall; (3)
             pulmonary artery systolic blood pressure is higher than 50 mmHg assessed by
             transthoracic echocardiography (defined as PAH), without left ventricular disease.

        Exclusion Criteria:





14 Years - 67 Years

Accepts Healthy Volunteers



Juhong Shi, M.D, , 

Location Countries


Location Countries


Administrative Informations



Organization ID

PUMCH-Pulmonary arteritis

Responsible Party


Study Sponsor

Peking Union Medical College Hospital

Study Sponsor

Juhong Shi, M.D, Study Chair, Peking Union Medical College Hospital

Verification Date

June 2017