Aerobic Capacity and Strength Exercise in Takayasu’s Arteritis

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Brief Title

Aerobic Capacity and Strength Exercise in Takayasu's Arteritis

Official Title

Aerobic Capacity and Strength Exercise in Takayasu's Arteritis: Impact on Clinical, Laboratory and Vascular Parameters

Brief Summary

      Takayasu's arteritis is a primary systemic vasculitis that affects large vessels and their
      main branches. The objectives of the present study were to assess: a) the aerobic capacity
      (CA); b) security of the acute strength exercise session; c) correlation between CA, as well
      as strength exercise session, with demographic, clinical, therapeutic, comorbid parameters,
      and presence and degree of vascular damage; d) serum levels of the cytokines
    

Detailed Description

      Takayasu's arteritis (TA) is a primary systemic vasculitis that affects large vessels and
      their main branches. It mainly affects young women. Blood vessel inflammation may result in
      stenosis, occlusions, ectasias and/or aneurysms and, consequently, difference of blood
      pressure between limbs and vascular claudication. Aerobic capacity (CA) is the measure of
      oxygen uptake, transport and use by the body, characterizing the individual's ability to
      perform activity. It is also a tool that can predict cardiovascular diseases. Our group has
      been a pioneer in demonstrating that CA is decreased in the small sample of the young women
      with TA. In addition, the safety and efficacy of aerobic exercises in this sample of patients
      were shown, as well as the influence of these sessions on the pro-inflammatory and angiogenic
      serum levels of the cytokines. However, due to the small samples, it was not possible to
      correlate CA with clinical and laboratory parameters and also with the presence of vascular
      damage. Moreover, to date, no studies have evaluated securityof an acute strength exercise
      session in TA.Therefore, thes objectives of the present study were to evaluate: a) the CA; b)
      security of the acute strength exercise session; c) correlation between CA, as well as
      strength exercise session, with demographic, clinical, therapeutic, comorbid parameters, and
      presence and degree of vascular damage; d) serum levels of the cytokine.
    


Study Type

Interventional


Primary Outcome

Security of acute session of combined physical exercises

Secondary Outcome

 Healthy Assessment Questionnaire (HAQ)

Condition

Physical Activity

Intervention

Combined acute physical exercises (strength and aerobic)

Study Arms / Comparison Groups

 Non physical exercises
Description:  Patients will not be submmitted to combined acute physical exercises (strength and aerobic)

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Other

Estimated Enrollment

12

Start Date

October 1, 2018

Completion Date

April 29, 2021

Primary Completion Date

April 29, 2021

Eligibility Criteria

        Inclusion Criteria:

          -  Classification criteria of Takayasu's arteritis

          -  Sedentarism

        Exclusion Criteria:

          -  Peripherical arterial diseases

          -  Non-controlled cardiovascular diseases

          -  Neurological diseases

          -  Patients with walking problem
      

Gender

All

Ages

18 Years - 50 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Contacts

Samuel K Shinjo, , 

Location Countries

Brazil

Location Countries

Brazil

Administrative Informations


NCT ID

NCT03750929

Organization ID

MYO-HCFMUSP-05


Responsible Party

Principal Investigator

Study Sponsor

University of Sao Paulo


Study Sponsor

Samuel K Shinjo, Principal Investigator, Universidade de Sao Paulo - Rheumatology Division


Verification Date

April 2021