Pressure Dependent Tracheal Obstruction in Copd Patients

Brief Title

Pressure Dependent Tracheal Obstruction in Copd Patients

Official Title

Pressure Dependent Tracheal Obstruction in Copd Patients

Brief Summary

      Background. Do pressure dependent tracheal obstructions (PDTO) often seen during bronchoscopy
      in COPD patients affect pulmonary function tests and breathing symptoms? Method. Model study.
      A garden hose was compressed from one side to simulate the posterior wall of the trachea
      bulging into the lumen. For two obstruction lengths - 3 cm and 12 cm, the hose was
      increasingly compressed in eight steps. Resistance was measured at each step for airflows 1
      l/s through 9 l/s, and digital photos of the luminal area were taken which were used by a
      computer to estimate the cross sectional area reduction and the corresponding distance
      between the bulging (posterior)and the opposite (anterior) wall (AP-distance).

      Patient study. 104 stable COPD patients studied by pulmonary function tests and bronchoscopy.
      The tracheal obstruction was observed during forced expiration and cough, and the cross
      sectional area reduction was estimated using the results from the model study.
    



Study Type

Observational




Condition

Tracheobronchomalacia



Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information



Estimated Enrollment

104

Start Date

August 2004

Completion Date

August 2011

Primary Completion Date

August 2006

Eligibility Criteria

        Inclusion Criteria:

          -  copd

        Exclusion Criteria:

          -  clinical evidence of malignant disease

          -  not able to be subjected to bronchoscopy
      

Gender

All

Ages

N/A - N/A

Accepts Healthy Volunteers

No

Contacts

Ivar Ellingsen, Dr med, , 

Location Countries

Norway

Location Countries

Norway

Administrative Informations


NCT ID

NCT01679808

Organization ID

GK-18

Secondary IDs

s-04058c

Responsible Party

Sponsor

Study Sponsor

LHL Helse


Study Sponsor

Ivar Ellingsen, Dr med, Principal Investigator, LHL Helse


Verification Date

September 2012