Peripheral Metabolic Effects of Somatostatin

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Brief Title

Peripheral Metabolic Effects of Somatostatin

Official Title

Peripheral Metabolic Effects of Intra Arterial Somatostatin Infusion in Healthy Controls

Brief Summary

      The aim of this study is to investigate peripheral effects of Somatostatin on glucose
      metabolism and growth hormone (GH) signalling in healthy men. Eight subjects will be
      enrolled. The hypothesis is that Somatostatin infusion reverses insulin resistance caused by
      GH.
    



Study Type

Interventional


Primary Outcome

Plasma levels of glucose

Secondary Outcome

 GH signalling

Condition

Acromegaly

Intervention

Somatostatin

Study Arms / Comparison Groups

 somatostatin
Description:  

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Drug

Estimated Enrollment

8

Start Date

October 2009

Completion Date

February 2010

Primary Completion Date

February 2010

Eligibility Criteria

        Inclusion Criteria:

          -  BMI < 27 kg/m2

          -  Written informed consent

          -  Healthy

        Exclusion Criteria:

          -  Any disease

          -  Any use of medications

          -  Present or previous malignancy

          -  Alcohol dependency

          -  Allergy to trial medication
      

Gender

Male

Ages

18 Years - 50 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Contacts

Jens Otto L Jørgensen, Professor, , 

Location Countries

Denmark

Location Countries

Denmark

Administrative Informations


NCT ID

NCT01062529

Organization ID

M-2008005


Responsible Party

Sponsor

Study Sponsor

University of Aarhus

Collaborators

 The Ministry of Science, Technology and Innovation, Denmark

Study Sponsor

Jens Otto L Jørgensen, Professor, Principal Investigator, 


Verification Date

January 2013