Management of Patients With Alpha-1 Antitrypsin Deficiency Associated Emphysema

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Alpha-1 antitrypsin deficiency
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Brief Title

Management of Patients With Alpha-1 Antitrypsin Deficiency Associated Emphysema

Official Title

Management of Patients With Alpha-1 Antitrypsin Deficiency Associated Emphysema. A National Registry.

Brief Summary

      The aim of this study is to describe the natural history of patients with alpha-1 antitrypsin
      associated emphysema and to figure out associated prognostic factors.

Detailed Description

      All patients who suffer from this disease are followed every 6 months during a 5 years
      period. FEV1 decline is the primary endpoint. Quality of life assessed using the Saint
      George's Respiratory Questionary is recorded too.

Study Type

Observational

Condition

Alpha 1-Antitrypsin Deficiency

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Estimated Enrollment

300

Start Date

February 2005

Completion Date

February 2012

Primary Completion Date

February 2011

Eligibility Criteria

        Inclusion Criteria:

          -  Serum alpha one antitrypsin < 0.8 g/l

          -  Emphysema diagnosed by CT scan

          -  Adult

          -  Obstructive disorder

        Exclusion Criteria:

          -  Liver or lung transplantation

Gender

All

Ages

18 Years - N/A

Accepts Healthy Volunteers

No

Contacts

Gabriel Thabut, MD, 1 40 87 57 12, [email protected]

Location Countries

France

Location Countries

France

Administrative Informations

NCT ID

NCT00700934

Organization ID

001

Study Sponsor

Assistance Publique - Hôpitaux de Paris

Study Sponsor

Gabriel Thabut, MD, Principal Investigator, Assistance Publique - Hôpitaux de Paris

Verification Date

June 2008