Brief Title
Management of Patients With Alpha-1 Antitrypsin Deficiency Associated Emphysema
Official Title
Management of Patients With Alpha-1 Antitrypsin Deficiency Associated Emphysema. A National Registry.
Brief Summary
The aim of this study is to describe the natural history of patients with alpha-1 antitrypsin
associated emphysema and to figure out associated prognostic factors.
Detailed Description
All patients who suffer from this disease are followed every 6 months during a 5 years
period. FEV1 decline is the primary endpoint. Quality of life assessed using the Saint
George's Respiratory Questionary is recorded too.
Study Type
Observational
Condition
Alpha 1-Antitrypsin Deficiency
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Estimated Enrollment
300
Start Date
February 2005
Completion Date
February 2012
Primary Completion Date
February 2011
Eligibility Criteria
Inclusion Criteria:
- Serum alpha one antitrypsin < 0.8 g/l
- Emphysema diagnosed by CT scan
- Adult
- Obstructive disorder
Exclusion Criteria:
- Liver or lung transplantation
Gender
All
Ages
18 Years - N/A
Accepts Healthy Volunteers
No
Contacts
Gabriel Thabut, MD, 1 40 87 57 12, [email protected]
Location Countries
France
Location Countries
France
Administrative Informations
NCT ID
NCT00700934
Organization ID
001
Study Sponsor
Assistance Publique - Hôpitaux de Paris
Study Sponsor
Gabriel Thabut, MD, Principal Investigator, Assistance Publique - Hôpitaux de Paris
Verification Date
June 2008