Investigation of Anatomical Correlates of Speech Discrimination

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Brief Title

Investigation of Anatomical Correlates of Speech Discrimination

Official Title

Investigation of Anatomical Correlates of Speech Discrimination

Brief Summary

      Understanding speech is essential for good communication. Individuals with hearing loss and
      poor speech discrimination often have little success with hearing aids because amplifying
      sound improves audibility, but not clarity of the speech signal. The purpose of this study is
      to determine the relative importance of the sensory cells of the inner ear and auditory
      neurons on speech discrimination performance in quiet and in noise. This information may be
      used as a predictor of hearing aid benefit. The investigators expect to find decreased speech
      understanding ability resulting from both loss of sensory cells and the loss of auditory
      neurons.
    



Study Type

Observational


Primary Outcome

Regression analysis


Condition

Sensorineural Hearing Loss

Intervention

Hearing Aid fitting

Study Arms / Comparison Groups

 low HIN difficulty- anesthetized
Description:  Subjects with normal OHC function and who will be undergoing an previously scheduled anesthetized procedure will be assigned into 2 groups based on their self-perceived HIN difficulty (high and low difficulty), and then undergo a test battery consisting of auditory threshold tests, objective HIN assays, OHC measurements, cognitive processing, and central auditory processing evaluations. Immediately after anesthetization, electrocochleography (ECochG) will be used to measure CAP amplitudes, which will be correlated with measurements obtained from unanesthetized subjects as described below. This aim will determine the optimal CAP recording method with the strongest correlation with HIN performance in humans

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Device

Estimated Enrollment

1652

Start Date

January 2013

Completion Date

August 2024

Primary Completion Date

January 2024

Eligibility Criteria

        Inclusion Criteria:

          -  Normal hearing to moderate sensorineural hearing loss

          -  Sufficient English proficiency to complete speech discrimination testing in English

        Exclusion Criteria:

          -  Hearing loss less than a 45 dB HL pure tone average (average hearing thresholds at
             500, 1000 and 2000 Hz)

          -  Conductive hearing loss

          -  Neurodegenerative disease
      

Gender

All

Ages

18 Years - 100 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Contacts

Mark Parker, PhD, , 

Location Countries

United States

Location Countries

United States

Administrative Informations


NCT ID

NCT01781039

Organization ID

00652


Responsible Party

Principal Investigator

Study Sponsor

Steward St. Elizabeth's Medical Center of Boston, Inc.


Study Sponsor

Mark Parker, PhD, Principal Investigator, Steward St. Elizabeth's Medical Center


Verification Date

April 2019