Brief Title
Investigation of Anatomical Correlates of Speech Discrimination
Official Title
Investigation of Anatomical Correlates of Speech Discrimination
Brief Summary
Understanding speech is essential for good communication. Individuals with hearing loss and
poor speech discrimination often have little success with hearing aids because amplifying
sound improves audibility, but not clarity of the speech signal. The purpose of this study is
to determine the relative importance of the sensory cells of the inner ear and auditory
neurons on speech discrimination performance in quiet and in noise. This information may be
used as a predictor of hearing aid benefit. The investigators expect to find decreased speech
understanding ability resulting from both loss of sensory cells and the loss of auditory
neurons.
Study Type
Observational
Primary Outcome
Regression analysis
Condition
Sensorineural Hearing Loss
Intervention
Hearing Aid fitting
Study Arms / Comparison Groups
low HIN difficulty- anesthetized
Description: Subjects with normal OHC function and who will be undergoing an previously scheduled anesthetized procedure will be assigned into 2 groups based on their self-perceived HIN difficulty (high and low difficulty), and then undergo a test battery consisting of auditory threshold tests, objective HIN assays, OHC measurements, cognitive processing, and central auditory processing evaluations. Immediately after anesthetization, electrocochleography (ECochG) will be used to measure CAP amplitudes, which will be correlated with measurements obtained from unanesthetized subjects as described below. This aim will determine the optimal CAP recording method with the strongest correlation with HIN performance in humans
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Device
Estimated Enrollment
1652
Start Date
January 2013
Completion Date
August 2026
Primary Completion Date
January 2026
Eligibility Criteria
Inclusion Criteria:
- Normal hearing to moderate sensorineural hearing loss
- Sufficient English proficiency to complete speech discrimination testing in English
Exclusion Criteria:
- Hearing loss less than a 45 dB HL pure tone average (average hearing thresholds at
500, 1000 and 2000 Hz)
- Conductive hearing loss
- Neurodegenerative disease
Gender
All
Ages
18 Years - 100 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Contacts
Mark Parker, PhD, ,
Location Countries
United States
Location Countries
United States
Administrative Informations
NCT ID
NCT01781039
Organization ID
00652
Responsible Party
Principal Investigator
Study Sponsor
Steward St. Elizabeth's Medical Center of Boston, Inc.
Study Sponsor
Mark Parker, PhD, Principal Investigator, Steward St. Elizabeth's Medical Center
Verification Date
June 2021