Brief Title
Immune Non-inferiority and Safety of a Vi-DT Typhoid Conjugate Vaccine
Official Title
A Phase III Multicenter, Observer-Blinded, Randomized, Active Controlled, Immune Non-inferiority and Safety Study of Vi-DT Vaccine Compared to Typbar TCV® in Healthy 6 Months-45 Years Aged Nepalese Participants.
Brief Summary
This is a Multicenter, observer-blinded, randomized, Active controlled, Phase 3 study in healthy 6 months to 45 years aged Nepalese at the time of the first vaccine dose. The study objectives are: I. Demonstrate non-inferiority of Vi-DT compared to Typbar TCV® as measured by seroconversion rates of anti-Vi IgG ELISA antibody titers, 4 weeks after single dose (pooled immunogenicity of three lots of Vi-DT) II. Demonstrate the equivalence of immunogenicity as measured by anti-Vi IgG GMT of three lots of Vi-DT vaccine 4 weeks after single dose.
Detailed Description
Subjects will be stratified according to age. The study procedure is as follows: Visit 1 (day-1 to -7): Screen participants by medical/medications history, physical examination, Vital signs, Urine pregnancy test (UPT) Visit 2 (day 0): Enroll, randomize and administer vaccine to eligible participants and assess participant safety by physical examination and Vital signs, Collect blood for immunogenicity assessments. Visit 3 (day 7): Check solicited adverse reaction 7 days post vaccination and Assess participant safety by physical examination and Vital signs Visit 4 (day 28): Assess participant safety by physical examination and Vital signs, Collect blood for immunogenicity assessments Visit 5 (day 84): Assess participant safety by physical examination and Vital signs Visit 6 (day 168): Assess participant safety by physical examination and Vital signs, Collect blood for immunogenicity assessments, and fill in study completion form in the absence of any safety concern. This study is observer-blind: vaccine administrator and vaccine safety evaluator will be two distinct persons to avoid bias of safety assessment. Trial staff other than the vaccine administrator. For retention: After vaccination, field health worker/designee will contact participant every day till Day 7 by physical visit or by phone call. Follow-up reminder calls will be done very frequently as per discretion of study staff until 24 weeks for all participant to assess participant safety.
Study Phase
Phase 3
Study Type
Interventional
Primary Outcome
Seroconversion rate1
Secondary Outcome
Geometric Mean Titers (GMT) 2
Condition
Typhoid
Intervention
Test Vaccine Vi-DT Typhoid conjugate
Study Arms / Comparison Groups
Test group A: Lot 1 Vi-DT (typhoid conjugate vaccine)
Description: One dose of Vi-DT (typhoid conjugate vaccine) Lot 1 will be administrated intramuscularly at Enrollment visit (Day 0). MR for age group at 9-15 months.
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Biological
Estimated Enrollment
1800
Start Date
November 15, 2019
Completion Date
January 2021
Primary Completion Date
September 2020
Eligibility Criteria
Inclusion Criteria: 1. Healthy participants 6 months to 45 years of age at enrollment 2. Participants/Parents/LAR who have voluntarily given informed consent/assent 3. Participants/Parents/LAR willing to follow the study procedures of the study and available for the entire duration of the study Exclusion Criteria: 1. Child with a congenital abnormality 2. Subject concomitantly enrolled or scheduled to be enrolled in another trial 3. Known history of immune function disorders including immunodeficiency diseases (Known HIV infection or other immune function disorders) 4. Chronic use of systemic steroids (>2 mg/kg/day or >20 mg/day prednisone equivalent for periods exceeding 10 days), cytotoxic or other immunosuppressive drugs 5. Receipt of blood or blood-derived products in the past 3 months 6. Subject with a previously ascertained or suspected disease caused by S. Typhi 7. Subject who have had household contact with/and or intimate exposure to an individual with laboratory-confirmed S. Typhi 8. Individual who has previously received a typhoid vaccine 9. Subject who has received or is expected to receive other vaccines from 1 month prior to IP vaccination to Visit 4 (approx.1 month post IP) except PVC booster as per EPI schedule 10. Known history or allergy to vaccines or other medications 11. History of uncontrolled coagulopathy or blood disorders 12. Any abnormality or chronic disease which in the opinion of the investigator might be detrimental for the safety of the subject and interfere with the assessment of the study objectives 13. Any female participant who is lactating, pregnant* or planning for pregnancy during the course of study period 14. Participants/Parents/LAR planning to move from the study area before the end of study period 15. As per Investigator's medical judgement individuals could be excluded from the study inspite of meeting all inclusion/exclusion criteria mentioned above Temporary Contraindication 16. Acute illness, in particular infectious disease or fever (axillary temperature ≥37.5°C), within three days prior to enrolment and vaccination. - Urine pregnancy test (UPT) will be performed in all married females prior to injection
Gender
All
Ages
6 Months - 45 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Contacts
Ganesh Kumar Rai, MD, ,
Location Countries
Nepal
Location Countries
Nepal
Administrative Informations
NCT ID
NCT03933098
Organization ID
IVI T003
Responsible Party
Sponsor
Study Sponsor
International Vaccine Institute
Collaborators
SK Bioscience Co., Ltd.
Study Sponsor
Ganesh Kumar Rai, MD, Principal Investigator, Kanti Children's Hospital
Verification Date
April 2020