Brief Title
Identification of Prognostic Gene Mutations in Biliary Tract Cancer Using Whole Genome Sequencing
Official Title
Identification of Prognostic Gene Mutations in Biliary Tract Cancer Using Whole Genome Sequencing
Brief Summary
The purpose of this study is to investigate genetic mutations affecting prognosis using whole
genome sequencing in patients with biliary tract cancer.
Detailed Description
Recently, as genome technology such as next-generation sequencing has progressed, precision
medicine using genetic analysis in lung cancer, colorectal cancer, and melanoma has been
actively studied. The need for such precision medicine is also increasing in biliary tract
cancer patients. Although whole genome sequencing is relatively costly, it is known to
provide more accurate information than other methods such as exome analysis and RNA
sequencing in identifying promoter mutations, regulatory regions, and structural variants.
Pancreatic cancer and melanoma have been studied by whole genome sequencing, but there is no
previous study using whole genome sequencing method in biliary tract cancer.
Study Type
Observational
Primary Outcome
Overall survival rate
Condition
Biliary Tract Cancer
Intervention
Endoscopic retrograde cholangiopancreatogram
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Diagnostic Test
Estimated Enrollment
100
Start Date
September 14, 2018
Completion Date
September 2, 2022
Primary Completion Date
September 2, 2020
Eligibility Criteria
Inclusion Criteria:
- Patients diagnosed with biliary tract cancer via endoscopic retrograde
cholangiopancreatogram
Exclusion Criteria:
- Pregnancy
- Other active tumors within 5 years
- Coagulopathy
- Severe mental illness
Gender
All
Ages
18 Years - N/A
Accepts Healthy Volunteers
No
Contacts
Ji Kon Ryu, MD, phD, 82-2-2072-2228, [email protected]
Location Countries
Korea, Republic of
Location Countries
Korea, Republic of
Administrative Informations
NCT ID
NCT03718897
Organization ID
1808-056-964
Responsible Party
Sponsor-Investigator
Study Sponsor
Ji Kon Ryu
Study Sponsor
Ji Kon Ryu, MD, phD, Study Director, Seoul National University Hospital
Verification Date
October 2018