Hyperprolactinemia and Adrenal Steroidogenesis

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Brief Title

Hyperprolactinemia and Adrenal Steroidogenesis

Official Title

Hyperprolactinemia and Adrenal Steroidogenesis: is There a Link?

Brief Summary

      The purpose of this study is to explore the effects of prolactin on adrenal steroid profiles
      in patients with hyperprolactinemia due to prolactinomas before and after initialisation of

Detailed Description

      Prolactin is known to influence many biological processes. One potential target is the
      adrenal gland, where prolactin may stimulate the production of adrenal steroid hormones.
      Conditions of increased prolactin production(hyperprolactinemia) could, therefore, increase
      concentrations of adrenal steroids. One of the potential implications would be false doping
      accusations of athletes engaging in elite sports.

      This interaction between prolactin and adrenal steroidogenesis, however, remains poorly
      understood, and the available research findings are conflicting.

      The investigators, therefore, seek to explore the relationship between prolactin and adrenal
      steroidogenesis by monitoring prolactin levels and blood and urinary steroid profiles of
      patients with hyperprolactinemia due to prolactinomas before and after treatment

Study Type


Primary Outcome

Covariation of plasma prolactin and plasma dehydroepiandrosterone

Secondary Outcome

 Change in the plasma steroid profile




* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Estimated Enrollment


Start Date

June 24, 2021

Completion Date

June 1, 2022

Primary Completion Date

May 1, 2022

Eligibility Criteria

        Inclusion Criteria:

          -  Aged 18 years or older

          -  Female and pre-menopausal

          -  Serum prolactin > 150 ng/ml

        Exclusion Criteria:

          -  Corticotropic and/or thyreotropic insufficiency

          -  Pregnancy, planned pregnancy or breastfeeding

          -  Physical or psychological condition likely to interfere with the normal conduct of the
             study and interpretation of the study results as judged by the investigator

          -  Incapacity to give informed consent




18 Years - N/A

Accepts Healthy Volunteers



Lia Bally, MD PhD, +41 (0)31 632 36 77, [email protected]

Location Countries


Location Countries


Administrative Informations



Organization ID


Responsible Party


Study Sponsor

University Hospital Inselspital, Berne

Study Sponsor

Lia Bally, MD PhD, Principal Investigator, Inselspital, Bern University Hospital, University of Bern

Verification Date

August 2021