High-intensity Interval Training and Mixed Meal Responses in Persons With Spinal Cord Injury

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Brief Title

High-intensity Interval Training and Mixed Meal Responses in Persons With Spinal Cord Injury

Official Title

The Effect of Upper-body High-intensity Interval Training on Postprandial Metabolic Control in Persons With Chronic Paraplegia

Brief Summary

      Persons with chronic paraplegia at an increased risk of developing cardiovascular disease and
      type-2 diabetes compared to the able-bodied population. There is mounting evidence from the
      able-bodied literature that high-intensity interval training (HIIT) is more effective than
      moderate-intensity continuous training (MICT) at improving markers of cardiometabolic health.
      Before we can understand the long-term training effects of HIIT in this population, it is
      important to compare the acute metabolic responses to a typical mixed-macronutrient meal
      following both exercise modalities.

      This study is recruiting adults (aged 18-65 years) with paraplegia (T2 or below) who
      sustained their spinal cord injury more than one-year ago. Participants will need to attend
      the laboratory at the University of Bath on four separate occasions, once for preliminary
      testing, and three times for study trials.
    

Detailed Description

      The aim of this research is to determine the metabolic responses to a mixed-meal tolerance
      test following a bout of HIIT and MICT in persons with chronic paraplegia. The hypothesis is
      that HIIT and MICT will be more effective at reducing the total triglyceride responses
      compared to a resting control condition.

      Preliminary measurements:

      Preliminary testing will include anthropometric measurements of supine length, weight, waist
      and hip circumferences, and resting blood pressure. There will also be an assessment of
      resting metabolic rate, sub-maximal and maximal exercise capacity, and a HIIT familiarisation
      session. All of the exercise protocols will take place on an arm crank ergometer at the
      University of Bath.

      Physical activity monitoring:

      For 7 days, participants will be fitted with a physical activity monitor (Actiheart™).
      Participants should not make any conscious changes to their normal lifestyle habits/routines
      during this period.

      Main trial days:

      In the 2 days prior to the main trial day, participants will be asked to record their food
      and drink intake and 48 hours before they should refrain from performing any strenuous
      physical activity. In the 24 hours prior participants should also refrain from consuming any
      alcohol or caffeine.

      Following a 10-hour overnight fast, an expired gas sample and venepuncture blood sample will
      be taken prior to exercise. Participants will then perform a bout of HIIT, MICT or a resting
      control condition. Following exercise, a cannula will be inserted into a vein and baseline
      blood sample(s) taken for analysis of metabolic markers.

      The participant will then be asked to consume a smoothie, consisting of peanut butter,
      banana, coconut oil, sugar, and chocolate-flavoured whey protein powder. The meal should be
      consumed within 10 minutes and blood samples will be taken from the cannula at 15, 30, 45 60,
      and 90 minutes and then at every hour for 6 hours after consumption of the meal to monitor
      changes in metabolic and inflammatory markers. Expired gas samples will also be taken hourly
      and indirect calorimetry will be used to estimate relative fat and carbohydrate metabolism in
      response to the meal.
    


Study Type

Interventional


Primary Outcome

Postprandial triglyceride concentrations

Secondary Outcome

 Postprandial glucose concentrations

Condition

Paraplegia

Intervention

Exercise

Study Arms / Comparison Groups

 Control
Description:  No exercise - 30-min of rest

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Other

Estimated Enrollment

11

Start Date

April 1, 2018

Completion Date

December 31, 2020

Primary Completion Date

December 31, 2020

Eligibility Criteria

        Inclusion Criteria:

          -  Individuals with a chronic (>12 months post-injury) SCI below T2

          -  Individuals who spend >75% of their waking day in a wheelchair

          -  Weight stable (weight not changed by >3% over the last 3 months)

        Exclusion Criteria:

          -  Individuals who an acute (<12 months post-injury) SCI

          -  Individuals who spend <75% of their waking day in a wheelchair

          -  Individuals on type-2 diabetes medication

          -  Individuals with a peanut allergy

          -  Individuals who self-report use of lipid-lowering agents

          -  Individuals self-reporting active medical issues (pressure sores, urinary tract
             infections, cardiac disorders, musculoskeletal complaints of the upper extremities, or
             cardiovascular contraindications to exercise testing)

          -  Individuals who report uncontrolled or regular autonomic dysreflexia
      

Gender

All

Ages

18 Years - 65 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Contacts

, 01225 383174, [email protected]

Location Countries

United Kingdom

Location Countries

United Kingdom

Administrative Informations


NCT ID

NCT04011137

Organization ID

EP 17/18 141


Responsible Party

Principal Investigator

Study Sponsor

University of Bath


Study Sponsor

, , 


Verification Date

July 2019