Effect of Sodium Lauryl Sulfate on Recurrent Aphthous Stomatitis
Effect of Sodium Lauryl Sulfate on Recurrent Aphthous Stomatitis : a Randomised Clinical Trial
Sodium lauryl sulfate (SLS) is an anionic detergent that has been used as the major or sole surfactant in most dentifrices. But it is known to local irritating factor to oral mucosa and skin and results in many side effects. This study was to compare the effects of SLS-free dentifrice and SLS-containing dentifrice in patients with recurrent aphthous stomatitis (RAS).
Number of episodes
Mean pain score
Recurrent Aphthous Stomatitis
sodium lauryl sulfate
Study Arms / Comparison Groups
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Primary Completion Date
Inclusion Criteria: - The volunteers had a history of regularly recurring oral ulcerations of at least 6 months duration, with more than one episode per month Exclusion Criteria: - already using an SLS-free dentifrice - taking medications affecting oral ulcers (e.g., corticosteroids) - having chronic oral mucosal disease (ex, lichen planus, pemphigus vulgaris, pemphigoid, and etc.) - having allergies to food or medications - being pregnant
N/A - N/A
Accepts Healthy Volunteers
Jeong-Seung Kwon, ,
Jeong-Seung Kwon, Study Director, Yonsei University dental hospital