Brief Title
Effect of Sodium Lauryl Sulfate on Recurrent Aphthous Stomatitis
Official Title
Effect of Sodium Lauryl Sulfate on Recurrent Aphthous Stomatitis : a Randomised Clinical Trial
Brief Summary
Sodium lauryl sulfate (SLS) is an anionic detergent that has been used as the major or sole
surfactant in most dentifrices. But it is known to local irritating factor to oral mucosa and
skin and results in many side effects. This study was to compare the effects of SLS-free
dentifrice and SLS-containing dentifrice in patients with recurrent aphthous stomatitis
(RAS).
Study Type
Interventional
Primary Outcome
Number of episodes
Secondary Outcome
Mean pain score
Condition
Recurrent Aphthous Stomatitis
Intervention
sodium lauryl sulfate
Study Arms / Comparison Groups
Group I
Description:
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Other
Estimated Enrollment
90
Start Date
January 2010
Completion Date
December 2010
Primary Completion Date
November 2010
Eligibility Criteria
Inclusion Criteria:
- The volunteers had a history of regularly recurring oral ulcerations of at least 6
months duration, with more than one episode per month
Exclusion Criteria:
- already using an SLS-free dentifrice
- taking medications affecting oral ulcers (e.g., corticosteroids)
- having chronic oral mucosal disease (ex, lichen planus, pemphigus vulgaris,
pemphigoid, and etc.)
- having allergies to food or medications
- being pregnant
Gender
All
Ages
N/A - N/A
Accepts Healthy Volunteers
No
Contacts
Jeong-Seung Kwon, ,
Administrative Informations
NCT ID
NCT01501409
Organization ID
2-2009-0012
Responsible Party
Principal Investigator
Study Sponsor
Yonsei University
Study Sponsor
Jeong-Seung Kwon, Study Director, Yonsei University dental hospital
Verification Date
December 2011