Effect of Sodium Lauryl Sulfate on Recurrent Aphthous Stomatitis

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Brief Title

Effect of Sodium Lauryl Sulfate on Recurrent Aphthous Stomatitis

Official Title

Effect of Sodium Lauryl Sulfate on Recurrent Aphthous Stomatitis : a Randomised Clinical Trial

Brief Summary

      Sodium lauryl sulfate (SLS) is an anionic detergent that has been used as the major or sole
      surfactant in most dentifrices. But it is known to local irritating factor to oral mucosa and
      skin and results in many side effects. This study was to compare the effects of SLS-free
      dentifrice and SLS-containing dentifrice in patients with recurrent aphthous stomatitis
      (RAS).
    



Study Type

Interventional


Primary Outcome

Number of episodes

Secondary Outcome

 Mean pain score

Condition

Recurrent Aphthous Stomatitis

Intervention

sodium lauryl sulfate

Study Arms / Comparison Groups

 Group I
Description:  

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Other

Estimated Enrollment

90

Start Date

January 2010

Completion Date

December 2010

Primary Completion Date

November 2010

Eligibility Criteria

        Inclusion Criteria:

          -  The volunteers had a history of regularly recurring oral ulcerations of at least 6
             months duration, with more than one episode per month

        Exclusion Criteria:

          -  already using an SLS-free dentifrice

          -  taking medications affecting oral ulcers (e.g., corticosteroids)

          -  having chronic oral mucosal disease (ex, lichen planus, pemphigus vulgaris,
             pemphigoid, and etc.)

          -  having allergies to food or medications

          -  being pregnant
      

Gender

All

Ages

N/A - N/A

Accepts Healthy Volunteers

No

Contacts

Jeong-Seung Kwon, , 



Administrative Informations


NCT ID

NCT01501409

Organization ID

2-2009-0012


Responsible Party

Principal Investigator

Study Sponsor

Yonsei University


Study Sponsor

Jeong-Seung Kwon, Study Director, Yonsei University dental hospital


Verification Date

December 2011