Curcumin and Nanocurcumin in Oral Aphthous Ulcer

Brief Title

Curcumin and Nanocurcumin in Oral Aphthous Ulcer

Official Title

Comparison of Curcumin and NanoCurcumin in Recurrent Aphthous Stomatitis

Brief Summary

      Recurrent aphthous ulcer is a painful inflammatory lesion with a high prevalence. Since the
      etiology is not clear, several strategies have been proposed to reduce pain and severity of
      its symptoms. Today, curcumin is considered as an herbal medicine with anti-inflammatory
      properties. Treatment or control of various inflammatory diseases has been proposed, but its
      low solubility in water has reduced bioavailability, while the use of nanoparticle
      pharmaceutical techniques has been able to solve these problems. Therefore, the aim of the
      present study was to evaluate the clinical efficacy of a new topical curcumin gel with
      nano-technology and compare it with 2% curcumin gel in patients with recurrent aphthous
      ulcers.

      This randomized clinical trial was performed on 48 patients assigned to two groups
      (nano-curcumin gel) and (curcumin gel). Before treatment, the size of the wound and VAS were
      measured. After intervention, the two variables were measured again on the fourth and seventh
      days , then the amount of improvement was quantitatively and qualitatively compared in the
      two groups and a significant level of less than 0.05 was considered.
    

Study Type

Interventional

Primary Outcome

Wound size

Condition

Recurrent Aphthous Ulcer

Intervention

Gel

Study Arms / Comparison Groups

 Curcumin

Description:  %2 Curcumin gel

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Status

Other

Estimated Enrollment

48

Start Date

July 15, 2018

Completion Date

March 1, 2020

Primary Completion Date

January 1, 2019

Eligibility Criteria

        Inclusion Criteria:

          -  Patients with minor and recurrent aphthous ulcer lesions within 48 hours and Aphthous
             like Lesions

        Exclusion Criteria:

          -  Wounds are in inaccessible areas (such as posterior palate). If a person suffers from
             systemic disease (through questioning the patient) Patients with turmeric allergy and
             any type of gel used in this study. Pregnant or lactating women .. accompany with
             other mucosal lesions. Do not take any other medicine while taking intervention Major
             or herpeti form of aphthous ulcer
      

Gender

All

Ages

N/A - N/A

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Contacts

, , 

Location Countries

Iran, Islamic Republic of

Location Countries

Iran, Islamic Republic of

NCT ID

NCT04385979

Organization ID

SBMU1

Responsible Party

Principal Investigator

Study Sponsor

Shahid Beheshti University of Medical Sciences

Study Sponsor

, , 

Verification Date

May 2020