Brief Title
Correlation of FC Gamma RIIIA Receptor Response in Patients With Waldenstrom's Macroglobulinemia
Official Title
Correlation of Fc Gamma RIIIA Receptor Expression and Response to Rituximab and Other Monoclonal Antibodies in Patients With Waldenstrom's Macroglobulinemia
Brief Summary
The purpose of this study is to determine if the type of Fc gamma RIIIa receptor that a particular patient's immune cells possess influences how they respond to rituximab and other monoclonal antibodies.
Detailed Description
- A medical data collection survey sheet will be filled out by the patient or doctor with medical information pertaining to how the patient responded to rituximab and other monoclonal antibodies for use in this study. - Blood work will be performed to analyze the blood by molecular technology to find the kind of Fc gamna RIIIa receptor the patient possess and correlate these findings with the outcome of treatment with rituximab or other monoclonal antibodies.
Study Type
Interventional
Condition
Waldenstrom's Macroglobulinemia
Intervention
Rituximab
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Drug
Estimated Enrollment
300
Start Date
January 2002
Completion Date
March 2007
Primary Completion Date
March 2007
Eligibility Criteria
Inclusion Criteria: - Patients treated with rituximab or other monoclonal antibodies for Waldenstrom's macroglobulinemia
Gender
All
Ages
30 Years - 90 Years
Accepts Healthy Volunteers
No
Contacts
Steven Treon, MD, MA, PhD, ,
Location Countries
United States
Location Countries
United States
Administrative Informations
NCT ID
NCT00142155
Organization ID
02-075
Study Sponsor
Dana-Farber Cancer Institute
Study Sponsor
Steven Treon, MD, MA, PhD, Principal Investigator, Dana-Farber Cancer Institute
Verification Date
June 2011