Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease

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Brief Title

Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease

Official Title

Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) II

Brief Summary

      The Division of Kidney Urology and Hematology Disease (DKUHD) of the National Institute of
      Diabetes and Digestive and Kidney Diseases (NIDDK) funded a cooperative agreement (UO1) for a
      consortium of participating clinical centers (PCCs) and a data coordinating and imaging
      analysis center (DCIAC) to develop and implement studies to test whether imaging techniques
      can provide accurate and reproducible markers of progression of renal disease in patients
      with polycystic kidney disease.

      The awarded participating clinical centers are Emory University, University of Kansas, and
      Mayo Foundation (with a subcontract to the University of Alabama). The awarded DCIAC is
      Washington University in St. Louis. Due to the relocation of the DCIAC P.I. from Washington
      University to the University of Pittsburgh, the DCIAC for CRISP II is located at the
      University of Pittsburgh.
    

Detailed Description

      The goal of the CRISP Study is to conduct a prospective, longitudinal trial to evaluate the
      accuracy and validity of magnetic resonance imaging to determine disease progression in ADPKD
      defined as a change in both renal and renal cyst volumes and renal function over time.
    


Study Type

Observational


Primary Outcome

kidney volume


Condition

Autosomal Dominant Polycystic Kidney Disease



Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information



Estimated Enrollment

211

Start Date

September 1999

Completion Date

March 2011

Primary Completion Date

March 2011

Eligibility Criteria

        Inclusion Criteria:

        1. CRISP I participants will be invited to participate in CRISP II. At entry into CRISP I
        participants met a number of inclusion and exclusion criteria.

        Exclusion Criteria:

          1. Current psychiatric or addiction or non-compliance disorder that in the discretion of
             the principal investigator indicates that the subject will not successfully complete
             the study;

          2. Current medical problem that in the discretion of the principal investigator would
             make unsafe the participation in the study;

          3. Inability to provide written informed consent
      

Gender

All

Ages

15 Years - 45 Years

Accepts Healthy Volunteers

No

Contacts

Marva Moxey-Mims, M.D., , 

Location Countries

United States

Location Countries

United States

Administrative Informations


NCT ID

NCT01039987

Organization ID

DK056961


Responsible Party

Principal Investigator

Study Sponsor

University of Pittsburgh

Collaborators

 National Institutes of Health (NIH)

Study Sponsor

Marva Moxey-Mims, M.D., Study Director, NIH, NIDDK, DKUH


Verification Date

August 2017