A New Diet for Patients With Autosomal Dominant Polycystic Disease (ADPKD)

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Brief Title

A New Diet for Patients With Autosomal Dominant Polycystic Disease (ADPKD)

Official Title

A New Diet for Patients With Autosomal Dominant Polycystic Disease (ADPKD)

Brief Summary

      Recent evidence has shown that kidney volume predicts the likelihood of developing renal
      insufficiency over a finite length of time in ADPKD, suggesting a linkage between the growth
      of cysts and the harm they do to kidney function. Recent studies indicate that the rate of
      kidney volume increase is hastened by excess dietary protein, salt, and potential net acid
      precursors, and slowed by increased water intake sufficient to lower plasma vasopressin
      levels.

      Diets are commonly prescribed to treat ADPKD and other renal patients with disease near the
      end-stage, but there is currently no specific diet prescription that takes potentially
      harmful dietary elements into account for ADPKD patients in the earliest stages of the
      disease. This study will examine a novel diet for ADPKD created by the researcher termed the
      ADPKD diet.
    



Study Type

Interventional


Primary Outcome

ADPKD diet impact on net acid excretion

Secondary Outcome

 Acceptance of ADPKD diet

Condition

Autosomal Dominant Polycystic Kidney Disease

Intervention

ADPKD Diet

Study Arms / Comparison Groups

 ADPKD Diet
Description:  All study participants will follow their regular diet for 8 days. After that, they will be asked to follow the ADPKD diet for a total of 4 weeks.

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Other

Estimated Enrollment

12

Start Date

February 2013

Completion Date

November 2014

Primary Completion Date

November 2014

Eligibility Criteria

        Inclusion Criteria:

          -  Have not been prescribed dietary restrictions or enhancements

          -  Blood pressure <135/85 mmHg with or without specific treatment

          -  Willingness to participate for at least one month

          -  Diet history consistent with the excretion of >30 mEq NAE / day based on usual dietary
             intake

        Exclusion Criteria:

          -  Other active diseases requiring pharmacologic agents

          -  Unstable weight (+/- 2 kg) for 3 months prior to enrollment

          -  Food allergies

          -  Pregnancy or lactating

          -  Confounding medications, i.e. bicarbonate, citrate

          -  Individuals who do not consume meat for personal, religious, or health reasons.
      

Gender

All

Ages

18 Years - 65 Years

Accepts Healthy Volunteers

No

Contacts

Debra Sullivan, PhD, RD, , 

Location Countries

United States

Location Countries

United States

Administrative Informations


NCT ID

NCT01810614

Organization ID

13493


Responsible Party

Sponsor

Study Sponsor

University of Kansas


Study Sponsor

Debra Sullivan, PhD, RD, Principal Investigator, University of Kansas Medical Center


Verification Date

August 2015