Blood and Cerebrospinal Fluid for Pediatric Brain Tumor Research

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Brief Title

Blood and Cerebrospinal Fluid for Pediatric Brain Tumor Research

Official Title

Collection of Blood and Cerebrospinal Fluid for Pediatric Brain Tumor Research

Brief Summary

      In normal patients, blood and cerebrospinal fluid (CSF) contain circulating cells and other
      molecules such as proteins and nucleic acids. In patients with central nervous system (CNS)
      and other conditions, the levels of these molecules may be altered. In several other studies
      at our institution, the investigators are investigating such molecules in tumor specimens as
      well as the blood and cerebrospinal fluid of pediatric patients with CNS tumors. However,
      these levels are difficult to interpret without comparing them to levels in patients without
      CNS tumors. The investigators propose a study to collect small amounts of blood and
      cerebrospinal fluid from pediatric patients without CNS tumors who are undergoing a
      diagnostic or therapeutic neurosurgical procedure aimed at addressing altered CSF dynamics.
    



Study Type

Observational


Primary Outcome

levels of miRNAs in the blood and CSF

Secondary Outcome

 Survivin and biologic markers levels in the CSF and blood

Condition

Hydrocephalus


Study Arms / Comparison Groups

 Children without central nervous system tumors
Description:  Children without central nervous system tumors between the ages of 1 year and 21 years who are undergoing a neurosurgical procedure to address hydrocephalus

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information



Estimated Enrollment

5

Start Date

July 2011

Completion Date

April 2012

Primary Completion Date

April 2012

Eligibility Criteria

        Inclusion Criteria:

          -  Children without central nervous system tumors who are undergoing a neurosurgical
             procedure to address hydrocephalus during which CSF will be obtained

          -  Between the ages of 1 year and 21 years

          -  Patients must be having blood draws, lumbar punctures or CSF sampling from Ommaya
             reservoirs or VPS as part of routine clinical care.

        Exclusion Criteria:

          -  Patients who do not require routine blood draws and/or CSF collection as part of their
             routine clinical care

          -  Patients who are considered too ill to participate as determined by their treating
             physician

          -  Patients with documented bacterial of viral infections of the CSF, brain parenchyma
             and/or neurosurgical devices and/or

          -  Patients with suspected de-myelinating conditions

          -  Patients who are pregnant or lactating.
      

Gender

All

Ages

1 Year - 21 Years

Accepts Healthy Volunteers

No

Contacts

Rishi Lulla, MD, , 

Location Countries

United States

Location Countries

United States

Administrative Informations


NCT ID

NCT01556178

Organization ID

2011-14612


Responsible Party

Principal Investigator

Study Sponsor

Ann & Robert H Lurie Children's Hospital of Chicago


Study Sponsor

Rishi Lulla, MD, Principal Investigator, Ann & Robert H Lurie Children's Hospital of Chicago


Verification Date

February 2016