Aneuploidy Rates of in Vitro Matured Oocytes

Brief Title

Aneuploidy Rates of in Vitro Matured Oocytes

Official Title

Aneuploidy Rates of in Vitro Matured Oocytes

Brief Summary

      In general, nearly 85% of retrieved oocytes are mature and reproductively useful after the
      retrieval, whereas the remaining percentage are still at metaphase I or germinal vesicle
      stage (MI: 4% and GV: 11 %, respectively).

      The objective of our study is to assess if immature oocytes co-cultured with autologous
      cumulus cells is a safer strategy than just leaving the oocytes in standard culture.
    

Detailed Description

      Under controlled ovarian stimulation, patients with normal functional ovarian reserves
      produce a good number of oocytes at retrieval. However, in addition to quantity, oocyte
      maturity is an important variable for the success of reproductive technologies. In general,
      nearly 85% of retrieved oocytes are mature and reproductively useful, whereas the remaining
      percentage are still at metaphase I or germinal vesicle stage (MI: 4% and GV: 11 %,
      respectively). Due to the limited expectations held for in vitro maturation in said
      stimulated cycles, the rescue of immature oocytes is not widely used in current clinical
      practice and these oocytes are usually discarded due to the possibility of abnormal embryonic
      development or an increased rate of abortion.

      The objective of our study is to assess if immature oocytes co-cultured with autologous
      cumulus cells is a safer strategy than just leaving the oocytes in standard culture.
    


Study Type

Observational


Primary Outcome

Aneuploidy rate


Condition

Aneuploidy

Intervention

Non intervention


Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Other

Estimated Enrollment

60

Start Date

March 27, 2019

Completion Date

September 30, 2019

Primary Completion Date

July 30, 2019

Eligibility Criteria

        Inclusion Criteria:

          -  18-35-year-old women

          -  BMI: >18 and < 30 kg/m2

          -  Normal female karyotype

          -  Normal uterus and ovaries at transvaginal ultrasound

        Exclusion Criteria:

          -  > 35 years

          -  PCO syndrome carriers

          -  Null follicle aspiration

          -  History of chemotherapy or radiotherapy
      

Gender

Female

Ages

18 Years - 35 Years

Accepts Healthy Volunteers

No

Contacts

, , 

Location Countries

Spain

Location Countries

Spain

Administrative Informations


NCT ID

NCT03860064

Organization ID

1810-BCN-071-ME


Responsible Party

Sponsor

Study Sponsor

IVI Barcelona


Study Sponsor

, , 


Verification Date

July 2019