Schistosomiasis Effect on Response to Vaccines, Anaemia and Nutritional Status of Children of Northern Senegal

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Brief Title

Schistosomiasis Effect on Response to Vaccines, Anaemia and Nutritional Status of Children of Northern Senegal

Official Title

Comparison of Schistosomiasis Diagnostic Techniques and Study of Schistosoma Infection on Children's Immune Response to Childhood Vaccines, on Anaemia and on Nutritional Status

Brief Summary

      SchistoVAN aims to study the role of schistosomiasis infection in the modulation of the
      immune response of children to childhood vaccine antigens, as well as the impact of this
      infection on their nutritional status and their haemoglobinaemia.
    

Detailed Description

      SchistoVAN aims to study the interactions between chronic parasite infections such as
      schistosomiasis and the immunological and nutritional status of children. In this scope, the
      investigators conducted a case-control study where one group of children is infected with
      schistosoma haematobium and the other is not infected with this parasite.

      The investigators then stimulated whole blood of these children with various vaccine antigens
      to address their immune function and study the influence of schistosomiasis infectious state
      on their overall immune condition.

      Aims of the study:

      To evaluate the interaction between schistosomiasis and the nutritional status of children
      and their haemoglobinemia.

      To evaluate the influence of schistosomiasis on children's specific immune response towards
      EPI vaccine antigens, the inflammatory status of children and nutritional serologic markers.

      To compare schistosomiasis diagnostic tools (evaluation of circulating cathodic antigen (CCA)
      strip for diagnosis of urinary schistosomiasis in comparison with microscopy and urinary
      dipsticks)

      To study prevalence of intestinal parasites such as Blastocystis hominis
    


Study Type

Observational




Condition

Schistosomiasis


Study Arms / Comparison Groups

 Infected by Schistosoma haematobium
Description:  

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information



Estimated Enrollment

99

Start Date

October 2011

Completion Date

October 2011

Primary Completion Date

October 2011

Eligibility Criteria

        Inclusion Criteria:

          -  Members of AnoPalAnoVac cohort

          -  Age: between 6 and 10 years

        Exclusion Criteria:

          -  body temperature > 38.5 ºC

          -  malaria episode
      

Gender

All

Ages

6 Years - 10 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Contacts

Emmanuel Hermann, PhD A.Pr., , 

Location Countries

Senegal

Location Countries

Senegal

Administrative Informations


NCT ID

NCT01553552

Organization ID

EPLS11-MS


Responsible Party

Sponsor

Study Sponsor

Biomedical Research Center EPLS

Collaborators

 Institut Pasteur de Lille

Study Sponsor

Emmanuel Hermann, PhD A.Pr., Study Chair, Biomedical Research Center EPLS


Verification Date

March 2012