Treatments

The following database contains products that have been granted orphan status, or have been market approval in the EU or the USA.

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Country Product Indication Sponsor Date
Triamcinolone acetonide Non-infectious uveitis S-cubed Ltd May 21, 2015
Poly-CD-PEG-camptothecin Ovarian cancer Cerulean Pharma, Inc.;35 Gatehouse Drive;Waltham, Massachusetts, 02451 May 21, 2015
Chloroquine Glioblastoma DualTpharma B.,V.;Boschstraat 111-D01, 6211 A W Maastricht; May 20, 2015
Xenon gas To improve neurological outcome in hospitalized cardiac arrest patients Neuroprotexeon;Imperial Innovations, London SW7 2PG; May 18, 2015
Revusiran Hereditary ATTR amyloidosis Alnylam Pharmaceuticals, Inc.;300 Third Street;Cambridge, Massachusetts, 02142 May 18, 2015
(S)-4-(8-amino-3-(1-but-2-ynoylpyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide Chronic lymphocytic leukemia Acerta Pharma BV;Molenstraat 110, 5342 CC Oss; May 13, 2015
Anti-eTau Humanized IgG4 Monoclonal Antibody Progressive supranuclear palsy Biogen, Inc.;225 Binney Street;Cambridge, Massachusetts, 02142 May 13, 2015
Acalabrutinib Chronic lymphocytic leukemia Acerta Pharma BV;Molenstraat 110, 5342 CC Oss; May 13, 2015
Recombinant human alkaline phosphatase Hypophosphatasia AM-Pharma BV;Rumpsterweg 6, 3891 AK Bunnik; May 13, 2015
2-(7-ethoxy-4-(3-fluorophenyl)-1-oxophthalazin-2(1H)-yl)-N-methyl-N-(2-methylbenzo[d]oxazol-6-yl)acetamide Cystic fibrosis Flatley Discovery Lab;529 Main Street, Suite 115;Charlestown, Massachusetts, 02129 May 13, 2015
Bruton’s Tyrosine Kinase (Btk) Inhibitor Chronic lymphocytic leukemia Acerta Pharma BV;Molenstraat 110, 5342 CC Oss; May 13, 2015
E-selectin antagonist Acute myeloid leukemia GlycoMimetics, Inc.;401 Professional Drive, Suite 250;Gaithersburg, Maryland, 20879 May 13, 2015
Adalimumab Hidradenitis suppurativa AbbVie, Inc.;1 North Waukegan Road;North Chicago, Illinois, 60064 May 13, 2015
Hydrocortisone oral granules Pediatric adrenal insufficiency (0 through 16 years of age) Diurnal Limited;Cardiff Medicentre, Cardiff CF14 4UJ; May 13, 2015
Edaravone Amyotrophic lateral sclerosis Mitsubishi Tanabe Pharma Corporation;17-10, Nihonbashi-Koamicho, Chuo-ku, Tokyo 103-8405; May 12, 2015
N-t-butylhydroxylamine Infantile neuronal ceroid lipofuscinosis Andrew Lim;California Institute of Technology, 1200 East California Blvd.;Pasadena, California, 91125 May 12, 2015
Autologous tumor cells fused with polyethylene glycol to human allogeneic FO-1, DNA plasmid transfected tumor cell line Glioblastoma Sebastiano Gattoni-Celli, MD;Med. University of SC- Dept of Radiation Oncology, 114 Doughty St.;Charleston, South Carolina, 29403 May 6, 2015
Humanized monoclonal antibody that targets the a-subunit of the human IL-3 receptor also known as the CD123 antigen; (JNJ-56022473) Acute myeloid leukemia Janssen Research & Development, LLC;920 Route 202, Box 300;Raritan, New Jersey, 08869 May 5, 2015
Tacrolimus Pulmonary Arterial Hypertension Stanford University School of Medicine;300 Pasteur Drive, Room H3143;Stanford, California, 94305 May 4, 2015
Pantothenate phosphate Pantothenate Kinase-associated neurodegeneration Retrophin, Inc.;777 Third Avenue, 22nd Floor;New York, New York, 10017 May 4, 2015
Pelareorep Stomach Cancer Oncolytics Biotech, Inc.;210, 1167 Kensington Crescent NW, Calgary AB T2N1X7; May 4, 2015
Tadalafil Duchenne muscular dystrophy Eli Lilly and Company;Lilly Corporate Center;Indianapolis, Indiana, 46285 May 4, 2015
4-(pyrimidin-2-ylmethyl)-7-[4-(trifluoromethoxy)phenyl]-3,4-dihydro-1,4-benzoxazepin-5(2H)-one Congenital long QT syndrome Gilead Sciences, Inc.;333 Lakeside Drive;Foster City, California, 94404 May 4, 2015
LOAd703, a modified adenovirus 5/35 containing a CMV promoter-driven transgene cassette with the human transgenes for a membrane-bound CD40 ligand (TMZ-CD40L) and full length 4-1BBL Pancreatic Cancer Lokon Pharma AB;Dag Hammarskjoldsvag 40c, 751 83, Uppsala; May 4, 2015
Antroquinonol Acute myeloid leukemia Golden Biotechnology Corporation;10F, No. 9, Ln. 3, Sec. 1, Zhong-Zheng E. Rd, New Taipei City 251; April 30, 2015