Chapel Hill, North Carolina – Despite affecting millions worldwide, Alzheimer’s disease (AD) has long lacked effective treatments due to a fundamental inadequacy of our understanding of its etiology and pathogenesis. The absence of an integrative theory connecting the molecular origins of AD with disturbances at the organelle and cell levels,...
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Göttingen, Germany – In a study with 991 adults, scientists at DZNE show that the most common forms of frontotemporal dementia (FTD) as well as the neurological diseases amyotrophic lateral sclerosis (ALS) and progressive supranuclear palsy (PSP) can be recognised by blood testing. Their procedure is not yet ready for...
London, UK – A new study led by researchers at UCL and the University of Sheffield, has demonstrated the potential of stem cell therapy to treat those with Hirschsprung disease. Hirschsprung disease is a rare condition where some nerve cells are missing in the large intestine. This means the intestine...
Scientists have found success in treating a ‘neglected’ inflammatory condition, polymyalgia rheumatica, with a drug that could provide an alternative to steroids for patients. The study, carried out by Anglia Ruskin University (ARU) and published in the New England Journal of Medicine, describes a successful trial of sarilumab. The drug,...
Amsterdam – After 40 years of treating metastatic bladder cancer with chemotherapy as a primary treatment, scientists now present a new approach using immunotherapy combinations. The results of not just one, but two studies have been presented at the European Society for Medical Oncology (ESMO) conference in Madrid. The outcomes...
Norwich, England – Researchers have been able to identify at least three distinct subtypes of a rare type of bone cancer for the first time, which could transform clinical trials and patient care.While genetic sequencing has previously helped to uncover different subtypes of other cancers, like breast or skin cancer,...
Toronto, Canada – Scientists at The Hospital for Sick Children (SickKids) have identified a key gene that could lead to next-generation treatments for medulloblastoma, the most common malignant brain tumour in children.Within cancerous tumours, there are special cells, called tumour-propagating cells, that drive tumour formation and growth. Since these cells...
BOSTON, Mass. — Brain disorders like Parkinson’s (PD) or Alzheimer’s Disease (AD) start to develop in patients much earlier than when their first clinical symptoms appear. Treating patients at these early stages could slow or even stop their disease, but there is currently no way to diagnose brain disorders at...
Bergen, Norway – University of Bergen researcher Markus Miettinen is among the first scientists to provide a detailed description of protein clumps associated with Huntington’s disease. The findings, which could pave the way for new diagnostic tools and treatments, were recently presented in an article in Nature Communications. “There is...
Beijing, China – Imagine the deep frustration of countless men who long to become fathers, only to face infertility due to a genetic condition they can’t control. For those with Klinefelter syndrome, this painful reality is a constant struggle. How does an extra X chromosome lead to infertility in men? Professor...