Ann Arbor, MI – Systemic sclerosis causes the skin to tighten and harden resulting in a potentially fatal autoimmune condition that is associated with lung fibrosis and kidney disease. University of Michigan Health researchers have studied the pathology of systemic sclerosis to understand better the disease and identify key pathways...
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ANN ARBOR, Michigan — Researchers at the University of Michigan Health Rogel Cancer Center are exploiting a unique biological feature of glioblastoma to gain a better understanding of how this puzzling brain cancer develops and how to target new treatments against it. The team, led by senior author Pedro Lowenstein,...
Ann Arbor, Mich. – Bacteria in the mouth may play a role in survival from idiopathic pulmonary fibrosis (IPF), finds a new study led by researchers from the University of Michigan and the University of Virginia. The findings come from a larger analysis of the role of the lung microbiome...
ANN ARBOR, Michigan — Researchers at the University of Michigan Health Rogel Cancer Center have uncovered a key reason why a typically normal protein goes awry and fuels cancer. They found the protein NSD2 alters the function of the androgen receptor, an important regulator of normal prostate development. When androgen...
ANN ARBOR, Michigan — When researchers at the University of Michigan Rogel Cancer Center first identified a new subtype of aggressive prostate cancer, they knew they needed to understand how this genetic alteration was driving cancer and how to target it with treatment. In two new papers, both published in Cell Reports Medicine, they...
Ann Arbor, Michigan – Researchers at the University of Michigan Health Rogel Cancer Center are one step closer to understanding how pediatric DIPG tumors work. Diffuse intrinsic pontine glioma, or DIPG, is the most aggressive pediatric brain tumor and incredibly difficult to treat since surgery isn’t feasible and recurrence is...
Ann Arbor, Mich. – Early treatment of pediatric Crohn’s disease with anti-tumor necrosis factor medications can substantially reduce the risk of perianal fistulas, a particularly debilitating complication of Crohn’s disease. Michigan Medicine researchers confirmed this finding using prospective data. The resulting paper, “Early tumour necrosis factor antagonist treatment prevents perianal...
Ann Arbor, Michigan – People with higher levels of metals found in their blood and urine may be more likely to be diagnosed with — and die from — amyotrophic lateral sclerosis, or ALS, a University of Michigan-led study suggests. Researchers have known that ALS, a rare but fatal neurodegenerative...
Milan, Italy – A study coordinated by Stefania Corti and Dario Ronchi of the Dino Ferrari Center at the University of Milan and the Policlinico Hospital of Milan has identified and characterized rare genetic variants in patients with spinal muscular atrophy (SMA), a serious, rare neuromuscular disease that damages motor...
Minneapolis, Minn. – Published in the Journal of Infectious Diseases, this research led by the University of Minnesota Medical School offers a new avenue of hope in the fight against chronic human immunodeficiency virus (HIV) infection. The researchers explored the use of Natural Killer (NK) cells aiming to restore their...