The Sigma-1 receptor (S1R) is a transmembrane protein with important roles in stabilizing cellular functions in both normal physiology and disease. Especially in neurodegenerative diseases, S1R’s activity has been shown to provide neuronal protection by stabilizing the cell environment (based on the movement of calcium ions), improving mitochondrial function and...
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Rockville, Maryland – New research conducted in mice offers insights into what’s going on at the molecular level that could cause people with diabetes to develop Alzheimer’s disease. The study adds to a growing body of research on the links between Type 2 diabetes and Alzheimer’s disease, which some scientists...
Davis, CA – A UC Davis Health study found that a single dose of Bacillus Calmette-Guérin (BCG), the vaccine for tuberculosis (TB), reduced liver tumor burden and extended the survival of mice with liver cancer. The study, published in Advanced Science, is the first to show the promising effects of...
Cologne, Germany – Small cell lung cancer (SCLC) is a highly aggressive tumor of the lung that occurs especially in heavy smokers. Due to the rapid spread of this tumour type, most patients can only be treated with chemotherapy with remarkable initial anti-tumour efficacy. However, relapse often occurs over the...
Helsinki, Finland – In many cancers, such as ovarian cancer, each round of chemotherapy kills the majority of cancer cells, while a small population of them survives treatment. Labeling cancer cells with genetic barcodes “In ReSisTrace, we label cancer cells uniquely with genetic barcodes and allow them to divide...
Lancaster, UK – Researchers at the University of Leeds and Lancaster University in the UK have identified a new potential target for the treatment of Alzheimer’s disease – PDE4B. Alzheimer’s disease is the leading cause of dementia and disability in old age. As the number of people diagnosed with Alzheimer’s...
CHAPEL HILL, N.C. – T cells are often called “assassins” or “killers” because they can orchestrate and carry out missions to hunt down bacteria, viruses, and cancer cells throughout the body. Mighty as they may be, recent research has shown that once T cells infiltrate the environment of a solid...
Chapel Hill, NC – University of North Carolina researchers have developed a new drug delivery platform that harnesses helical amyloid fibers designed to untwist and release drugs in response to body temperatures. A new research paper published in Nature Communications reveals groundbreaking structural details into how diseases form much like...
Norman, Oklahoma – Vitamin B6 is beneficial in many ways, notably for its role in maintaining a strong immune system. However, when pancreatic cancer develops, its cells also need vitamin B6 to replicate. During the ensuing tug of war over a limited supply of vitamin B6, pancreatic cancer almost always...
BUFFALO, NY – A new research paper was published in Genes & Cancer entitled, “Roles of USP1 in Ewing sarcoma.” Ewing sarcoma is a cancer of bone and soft tissue in children and young adults that is driven by the EWS-ETS fusion transcription factor, most commonly EWS-FLI1. Researchers Panneerselvam Jayabal,...