research News

Results of a retrospective analysis showed a significantly elevated risk of bone fractures in a population-based cohort of patients with myeloproliferative neoplasms (MPNs), particularly polycythemia vera (PV), compared with the overall population. These findings were published in Leukemia and Lymphoma. The Philadelphia chromosome-negative MPNs, characterized by clonal proliferation of 1 or more...
A national Radiation Therapy Oncology Group (RTOG) study led by a Medical College of Wisconsin Cancer Center physician at Froedtert Hospital in Milwaukee has found that a course of radiation therapy to the brain after treatment for locally advanced non-small cell lung cancer reduced the risk of metastases to the...
Altering a protein linked to Rett syndrome so that it cannot bind to a particular type of DNA tag results in traits reminiscent of the syndrome, according to a new study in mice. The findings could help explain the syndrome’s delayed onset in people: Because the tag does not arise until after...
Coronary artery bypass surgery provides long-term benefits for children whose hearts and blood vessels are damaged by Kawasaki disease, Japanese researchers report in Circulation: Journal of the American Heart Association. Researchers followed 114 people for up to 25 years who had bypass surgery as children or adolescents (ages 1 to...
Examination of Japanese cases of gynecological cancer offers a better understanding of the profile of a rare ovarian tumor and could change treatment guidelines. Ovarian granulosa cell tumors are a rare type of ovarian cancer that affect the ovaries and fallopian tubes, and can extend further into the pelvis and...
The University of California, San Francisco (UCSF) and the Multiple Myeloma Research Foundation (MMRF) have established the Stephen and Nancy Grand Multiple Myeloma Translational Initiative, a research collaboration dedicated to translating basic science discoveries into new candidate drugs for testing in clinical trials. The initiative, known as MMTI, was launched...
Among patients with refractory large B cell lymphoma (LBCL), chimeric antigen receptor (CAR)-T cell therapy appears to yield superior long-term clinical outcomes to those seen with standard salvage therapy regimens, according to an analysis published in Blood Advances. Treatments for LBCL, the most common non-Hodgkin lymphoma subtype, have improved over the...
Chimeric antigen receptor T-cell (CAR-T) therapy has demonstrated effectiveness and safety in relapsed/refractory multiple myeloma (RRMM), according to a meta-analysis published in the International Journal of Medical Sciences. RRMM treatments have come a long way and have drastically improved overall survival, but the disease remains incurable. CAR-T therapy has led to...
MADISON — A fundamental question about how sugar units are strung together into long carbohydrate chains has also pinpointed a promising way to target new medicines against tuberculosis. Working with components of the tuberculosis bacterium, researchers from the University of Wisconsin-Madison identified an unusual process by which the pathogen builds...
DURHAM, N.C. — Restricting carbohydrates, regardless of weight loss, appears to slow the growth of prostate tumors, according to an animal study being published this week by researchers in the Duke Prostate Center. “Previous work here and elsewhere has shown that a diet light in carbohydrates could slow tumor growth,...