Washington, D.C. — Vaccines that prevent smallpox and mpox come in 2 varieties. One uses a single shot of a live virus but carries risk of serious side effects; the other, which is newer and made with replication deficient virus, has fewer side effects but requires 2 doses. An experimental...
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New York, NY – Two new studies led by researchers at Hospital for Special Surgery (HSS) have uncovered key biological mechanisms driving systemic sclerosis (SSc), or scleroderma – a rare and often devastating autoimmune disease that causes fibrosis (tissue hardening) and inflammation. The research, published in the March issue of...
LA JOLLA, CA — Scientists from Scripps Research have developed a small molecule that blocks the activity of a protein linked to autoimmune diseases, including systemic lupus erythematosus (SLE) and Crohn’s disease. This protein, known as SLC15A4, has been considered largely “undruggable,” as most researchers had longed struggled to isolate...
LOS ANGELES, Calif. – For the last three decades, breakthroughs have been sparse for soft tissue sarcomas, which are rare cancers that affect muscles, fat and other connective tissues. Today, a global team of researchers funded by a Stand Up To Cancer® (SU2C) grant announced clinical trial results that point...
AB Science SA today announced the publication of a peer-reviewed article in which the authors state that blocking hemichannels on mast cells with masitinib represents a promising novel strategy for slowing the progression of neurodegenerative diseases such as Alzheimer’s disease and amyotrophic lateral sclerosis (ALS). Hemichannels allow cell communication with...
Leuven, Belgium – Charcot-Marie-Tooth disease (CMT), a group of heritable disorders that affect the peripheral nerves, is marked by specific genetic changes. Research by the team of Prof. Ludo Van Den Bosch (VIB-KU Leuven) now reveals the effects of one such genetic cause. They found that the duplication of the...
Researchers from the Princess Máxima Center, the Netherlands Cancer Institute, and Oncode Institute have unearthed valuable knowledge about the origin of rhabdoid tumors, an aggressive form of cancer diagnosed in children, through studying mini, lab-grown tumors. Their research has managed to identify a potential target for future therapies. Utrecht,...
COPENHAGEN – A grant from the Novo Nordisk Foundation of up to 300 million euros now enables the establishment of a major international research center focused on stem cell medicine. The center will be a collaboration between the University of Copenhagen, Denmark, Murdoch Children’s Research Institute, Australia, and Leiden University Medical Center, The Netherlands. The partnership...
Osaka, Japan – Hypophosphatasia is a relatively common skeletal disease that primarily affects bone and tooth strength. In the third national dental survey of hypophosphatasia in Japan, recently published in Scientific Reports, researchers analyzed the dental issues faced by Japanese patients in their largest survey to date. Their findings provide...
PHILADELPHIA – New research from Jefferson Hospital for Neuroscience (JHN) may redefine how Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) is diagnosed. Eduardo De Sousa, M.D., assistant professor of Neurology at Jefferson Medical College of Thomas Jefferson University, and director of the Electrodiagnostic Neuromuscular Lab at JHN, led the study which looked...