Mānoa, Hawai’i – For decades, scientists have dreamt of a future where genetic diseases, such as the blood clotting disorder hemophilia, could be a thing of the past. Gene therapy, the idea of fixing faulty genes with healthy ones, has held immense promise. But a major hurdle has been finding...
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Hong Kong – A research team led by Professor Chaogu ZHENG from the School of Biological Sciences at The University of Hong Kong (HKU) recently discovered that propionate, a short-chain fatty acid (SCFA), strongly suppressed neurodegeneration in animal models of Parkinson’s disease (PD) by regulating interorgan signalling between the intestine...
CHAMPAIGN, Ill. — A surge of a neural-specific protein in the brain is the earliest-yet biomarker for Alzheimer’s disease, report University of Illinois Urbana-Champaign researchers studying a mouse model of the disease. Furthermore, the increased protein activity leads to the seizures associated with the earliest stages of neurodegeneration, and inhibiting...
Jyväskylä, Finland – In his doctoral dissertation completed at the University of Jyväskylä, Finland, Tero Sievänen demonstrates that the cancer risk of Lynch syndrome carriers can be assessed based on circulating microRNA profiles. This helps in developing current screening methods and targeting screenings for high-risk individuals. Additionally, the study corroborates...
Leeds, England – A rare disorder which causes babies to be born with extra fingers and toes and a range of birth defects has been identified in new research co-led by the University of Leeds. The disorder, which has not yet been named, is caused by a genetic mutation in...
Baltimore MD – A drug approved to treat pulmonary arterial hypertension may be effective at managing hypertension and end-organ damage in patients with sickle cell disease, according to a new study published in Lancet Haematology. An early phase randomized clinical trial involving 130 patients with sickle cell disease found that...
MIAMI, FLORIDA – New research from Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine and collaborating organizations has identified a next-generation BTK degrader that could help overcome treatment resistance in chronic lymphocytic leukemia (CLL) and related blood cancers. Their findings, published in the journal Science,...
Ann Arbor, MI – Systemic sclerosis causes the skin to tighten and harden resulting in a potentially fatal autoimmune condition that is associated with lung fibrosis and kidney disease. University of Michigan Health researchers have studied the pathology of systemic sclerosis to understand better the disease and identify key pathways...
ANN ARBOR, Michigan — Researchers at the University of Michigan Health Rogel Cancer Center are exploiting a unique biological feature of glioblastoma to gain a better understanding of how this puzzling brain cancer develops and how to target new treatments against it. The team, led by senior author Pedro Lowenstein,...
Ann Arbor, Mich. – Bacteria in the mouth may play a role in survival from idiopathic pulmonary fibrosis (IPF), finds a new study led by researchers from the University of Michigan and the University of Virginia. The findings come from a larger analysis of the role of the lung microbiome...